نتایج جستجو برای: solid microneedles
تعداد نتایج: 189993 فیلتر نتایج به سال:
Microneedles (MN) have the potential to become a highly progressive device for both drug delivery and monitoring purposes as they penetrate skin pierce stratum corneum barrier, allowing of drugs in viable layers extraction body fluids. Despite many years research different types MN developed, only hollow reached pharmaceutical market under path medical devices. Therefore, this review focuses on...
Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim of this study was to describe the polymer selection, and optimize formulation compounding parameters for various polymeric MNs. Inve...
BACKGROUND Simple and effective vaccine administration is particularly important for annually recommended influenza vaccination. We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy. METHODOLOGY/PRINCIPAL FINDINGS Solid microneedle arrays coated with inact...
The efficacious delivery of antigens to antigen-presenting cells (APCs), in particular, to dendritic cells (DCs), and their subsequent activation remains a significant challenge in the development of effective vaccines. This study highlights the potential of dissolving microneedle (MN) arrays laden with nanoencapsulated antigen to increase vaccine immunogenicity by targeting antigen specificall...
Drugs are administered by using different drug delivery systems. A number of drug delivery systems have evolved over the years. In the last 20 years TDDS (Transdermal drug delivery system) has been growing at a rapid pace. Now the micro needles are being developed as a novel drug delivery system. The micro needle skin patch system is also a drug delivery system, which will be used transdermally...
To determine whether a microneedle patch combined with 5% topical lidocaine reduces dental injection pain more than without microneedles lidocaine. This proof of principle randomised, two-treatment, double-blind, crossover split-unit design study in 16 healthy participants investigated levels perceived from 3 increasing provoking challenges, when gel was applied to the oral mucosa and no micron...
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