Background: The skin is the largest organ of body and provides main barrier between internal external environment. Assessment permeability critical importance for understanding predicting in vivo efficacy bioavailability bioactive phenolic compounds. Objectives: This study investigated relationship compounds using silico methods. Methods: Screening was performed on 475 randomly selected Molecul...

conclusions diclofenac-loaded nanoparticles based on properties of chitosan gelation could delay the release of drugs in the stomach and be further evaluated for the enteric delivery of diclofenac. objectives the aim of this study was to prepare and evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. materials and methods chitosan (cs) nanoparticles contai...

4-Coumarate:coenzyme A ligase (4CL) plays a key role in phenylpropanoid metabolism, providing precursors for a large variety of important plant secondary metabolites, such as lignin, flavonoids, and phytoalexins. Although 4CLs have been believed to be specific to plants, a gene encoding a 4CL-like enzyme which shows more than 40% identity in amino acid sequence to plant 4CLs was found in the ge...

In the cell walls of grasses, ferulic acid is esterified to arabinoxylans and undergoes oxidative reactions to form ferulates dimers, trimers and oligomers. Feruloylation of arabinoxylan is considered important not only because it leads to cross-linked xylans but also because ferulates may act as a nucleating site for the formation of lignin and hence link arabinoxylans to lignin by forming a l...

Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase than normal healthy rats, and the activation of this signaling pathway leads to portal hypertension. Sodium ferulate (SF) has been shown to decrease the production of geranylgeranyl pyrophosphate (GGPP), a substance essential for RhoA activation. In the present study, to investigate the effects of SF on fibrosis, portal...

Trong nghiên cứu này, thành phần hóa học của cao chiết ethyl acetate từ thân và lá cây ba chẽ đã được cứu. Mẫu nguyên liệu khô được nghiền nhỏ, sau đó bằng phương pháp ngấm kiệt với methanol thu thô. Cao chiết thô phân tán trong nước và thực hiện quá trình lỏng- lỏng dung môi nhằm acetate. tách sắc ký trên cột silica gel Sephadex LH20. Kết quả lập bốn hợp chất sạch. Dựa vào dữ phổ 1H-NMR 13C-NM...

Activity-directed fractionation and purification processes were employed to identify the anti-Alzheimer active compounds from the root of Angelica sinensis. In the present study, the ability of Angelica root to inhibit the aggregated amyloid β-peptide (agg Aβ1-40) induced damage of differentiated PC-12 cells (dPC-12), a well-known cell model for Alzheimer disease, was investigated. Air-dried ro...