BACKGROUND There is only one established drug binding site on sodium channels. However, drug binding of sodium channels shows extreme promiscuity: ∼25% of investigated drugs have been found to potently inhibit sodium channels. The structural diversity of these molecules suggests that they may not share the binding site, and/or the mode of action. Our goal was to attempt classification of sodium...

methanesulfonic acid (msa) was found to be an efficient catalyst for the synthesis of 1-substituted-1h-1,2,3,4-tetrazoles. a series of 1-substituted tetrazole compounds were synthesized from the reaction of various primary amines, sodium azide and triethyl orthoformate in the presence of catalytic amounts of msa at room temperature. in this protocol, some of the tetrazole derivatives were synth...

This work involved the synthesis of tetrazole derivatives 4,4'-(((sulfonylbis(4,1-phenylene))bis(diazene-2,1-dil))bis(2-(1-(4-R)phenyl]-4),5-Dihydro-1H-tetrazol-5-yl(phenol) (where R = OH or OCH3) through reaction substituted amine in THF as a solvent, with sodium azide. FT-IR 1H-NMR Spectrophotometric methods were used to characterize prepared compounds, antibacterial activity against four typ...

Lettuce is a leafy vegetable widely used in industry for minimally processed products, in which the step of sanitization is the crucial moment for ensuring a safe food for consumption. Chlorinated compounds, mainly sodium hypochlorite, are the most used in Brazil, but the formation of trihalomethanes from this sanitizer is a drawback. Then, the search for alternative methods to sodium hypochlor...

Shedlovsky's results,16 which differ from all others. There can be no doubt that most if not all, of these minima are spurious. One observation, which we have made may have an important bearing on this problem. In many cases, on addition of the first sample, the resistance of the solution drifted to lower values. The rate of this drift depended on the salt as well. as on the sample. In some ins...

Efficient syntheses of four aminocyclitols are reported. Each synthesis is accomplished in eight steps starting from D-(-)-quinic acid. The key step involves a highly regioselective ring opening of epoxides by sodium azide.

A new family of fluorine-free solid-polymer electrolytes, for use in sodium-ion battery applications, is presented. Three novel sodium salts withdiffuse negative charges: sodium pentacyanopropenide (NaPCPI), sodium 2,3,4,5-tetracyanopirolate (NaTCP) and sodium 2,4,5-tricyanoimidazolate (NaTIM) were designed andtested in a poly(ethylene oxide) (PEO) matrix as polymer electrolytes for anall-solid...

A new series of Mannich bases MK8-12 has been synthesized from 1, 2, 4thiadiazole by Mannich reaction. All the synthesized compounds of the series displayed, remarkable analgesic activity in comparison to standard drug diclofenac sodium. In the synthesized thiadiazole derivatives MK-8 & MK-10 showed activity at 20mg/kg . MK-9 & MK-11 are considered as most active compounds as they protected 60....