نتایج جستجو برای: sodium channels
تعداد نتایج: 317357 فیلتر نتایج به سال:
Voltage-gated sodium channels are unique in that they combine action potential conduction with cell adhesion. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The alpha subunits are members of a large gene family containing the voltage-gated sodium, potassium, and calcium channels. Sodium channel alpha subunits form ...
introduction: purkinje cell (pc) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. here, the spectral analysis of pcs firing in control, 3-acety...
Inflammatory molecules sensitize peripheral nociceptors, making them responsive to innocuous stimuli. Sensitization is mediated by protein kinase A (PKA), but the ion channels involved are not known. PKA increases expression of voltage-gated sodium channels, but knock-out of these channels does not eliminate inflammation-induced sensitization. PKA also decreases potassium currents, but the perc...
Norepinephrine and carbamoylcholine stimulate accumulation of [3H]inositol phosphates from [3H]inositol-labeled guinea pig cerebral cortical synaptoneurosomes through interaction with alpha 1-adrenergic and muscarinic receptors, respectively. In addition to such agonist, a variety of natural products that affect voltage-dependent sodium channels can markedly stimulate accumulation of [3H]inosit...
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