Suppressor of cytokine signaling 1 (SOCS1) mutations are among the most frequent somatic mutations in classical Hodgkin lymphoma (cHL), yet their prognostic relevance in cHL is unexplored. Here, we performed laser-capture microdissection of Hodgkin/Reed-Sternberg (HRS) cells from tumor samples in a cohort of 105 cHL patients. Full-length SOCS1 gene sequencing showed mutations in 61% of all case...

Respiratory syncytial virus (RSV) infection upregulates genes of the suppressor of cytokine signaling (SOCS) family, which utilize a feedback loop to inhibit type I interferon dependent antiviral signaling pathway. Here, we reconstituted RSV nonstructural (NS) protein expression plasmids (pNS1, pNS2, and pNS1/2) and tested whether NS1 or NS2 would trigger SOCS1 and SOCS3 protein expression. The...

Constitutive activation of Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT) signaling has an important role in the oncogenesis of myeloproliferative neoplasms (MPNs) and leukemia. Histone deacetylases (HDACs) inhibitors have been reported to possess anticancer activity through different mechanisms. However, whether HDACs inhibitors suppress JAK2/STAT signaling in MP...

يديوتامورلا لصافلما باهتلا ضيرم180 ةساردلا تلمش :جئاتنلا عافترا نأ جئاتنلا ترهظأ .)اًماع 40.49±12.19 رمعلا طسوتم( يف LDL لدعم و )55.1%(لورتسلوكلا لدعم عافترا راشتنا لدعم عافترا ينب ةيئاصحإ ةوق تاذ ةقلاع دوجو نع تفشك .)51.2%( ىلع ةولاعو .)p=0.002( CRP لا هبسن عافترا و لورتسيلوكلا طاشنو يلكلا لورتسلوكلا ينب ةيباجيإ ةقلاع دوجو انظحلا ،كلذ طاقن رخآ ضرم ةكرتشلما اًماع 28 مادختساب اهسايق تم امك ،ضرلما ...

Suppressors of Cytokine Signaling (SOCS) family members are inhibitors of cytokine signaling pathways. Emerging evidence suggests the involvement of SOCS1 and SOCS3 in a variety of diseases, including allergy, autoimmune diseases, and inflammation. This study aimed to investigate the expression of SOCS1 and SOCS3 in the development of Henoch-Schoenlein Purpura (HSP) in children. Peripheral Bloo...

Therapeutic effects of green tea involve an inhibitory function of its constituent polyphenol epigallocatechin gallate (EGCG) on cell signaling. The specificity and mechanism(s) by which EGCG inhibits cell signaling have remained unclear. Here, we demonstrate that green tea and EGCG induce suppressor of cytokine signaling 1 (SOCS1) gene expression, a negative regulator of specific cell signalin...

PURPOSE We aimed to investigate whether miR-19a is associated with neuropathic pain and elucidate the underlying regulatory mechanism. METHODS We established a neuropathic pain model of bilateral chronic constriction injury (bCCI). Then bCCI rats were injected with mo-miR-19a, siR-SOCS1 or blank expression vector through a microinjection syringe via an intrathecal catheter on 3 day before sur...

Fibroblast growth factor receptor (FGFR) signaling is transduced by the mitogen-activated protein kinase (MAPK) cascade and the signal transducers and activators of transcription (STATs). Suppressors of cytokine signaling (SOCS) proteins are expressed in response to cytokine-inducible stimulation of STAT phosphorylation, acting in a negative-feedback mechanism to hinder the activities of these ...

The effect of base temperature variation on the heat transfer from unsteady state annular heat sink of cooling microelectronic device. Three types of the base temperature variation equations are taken in the present study. The Sine wave variation, Cosine wave variation & exponential variation of the base temperature. The finite element technique based on Galerkin method with axisymmetric rectan...