BACKGROUND Genetic polymorphisms, gender and age all influence the risk of developing chronic neuropathic pain following peripheral nerve injury (PNI). It is known that there are significant inter-strain differences in pain hypersensitivity in strains of mice after PNI. In response to PNI, one of the earliest events is thought to be the disruption of the blood-spinal cord barrier (BSCB). The st...

OBJECTIVE To examine the salubrious role of social interaction in modulating the development of allodynia (increased sensitivity to typically innocuous physical stimuli) and depressive-like behavior post peripheral nerve injury in mice. The determination of potential mechanisms that mediate social influences on the behavioral and physiological response to peripheral nerve injury. METHODS Mice...

OBJECTIVES This study investigated the antidepressant and antinociceptive effects of ethanolic extract (SLEE) and pure fruticuline A obtained from Salvia lachnostachys leaves on rats and mice. METHODS In this study, SLEE (100 mg/kg, p.o. route) was evaluated for its effects on spared nerve injury (SNI) in rats. The animals were submitted to mechanical sensitivity, forced swim (FST) and cold s...

The centrosymmetric title compound, [SnI(4)(C(21)H(21)OP)(2)], is a monomeric complex that displays a nearly octa-hedral coordination of tin(IV), with an Sn-O bond distance of 2.159 (2) Å and an average Sn-I bond distance of 2.79 (3) Å.

Gedung Guest House Gubernuran Sumbar merupakan sebuah bangunan yang dibangun dengan jenis struktur beton bertulang, terdiri dari dua lantai, dan berfungsi sebagai tempat penginapan bagi tamu-tamu gubernur. Penelitian ini bertujuan untuk membandingkan hasil desain elemen oleh perencana saya dapatkan. Pada analisis ini, menggunakan acuan Standar SKSNI T-15-1991-03 perhitungan Perencanaan Ketahana...

This study is a field research that aims to determine the extent of green open spaces that serve asneighborhood parks in Housing Public Company Panakkukang, which consists of three areas: Toddopuli, Tidung,and Tamalate. Population in this study, is the third of the areas. The selected sample is Tamalate, arguing that thearea is in the middle and is central to the whole Housing Public Company Pa...

BACKGROUND After peripheral nerve injury, spontaneous ectopic activity arising from the peripheral axons plays an important role in inducing central sensitization and neuropathic pain. Recent evidence indicates that activation of spinal cord microglia also contributes to the development of neuropathic pain. In particular, activation of p38 mitogen-activated protein kinase (MAPK) in spinal micro...