Radiotherapy is the most commonly used treatment modality for patients with lung cancer in the UK, with established, although frequently ignored, indications. It has a role in early, medically inoperable, and locally advanced unresectable non-small cell lung cancer (NSCLC), where some patients are cured, in the palliation of advanced lung cancer of all types, and in the adjuvant treatment of li...

Combined chemotherapy and radiation therapy have started to replace the traditional local approach of thoracic radiotherapy alone for unresectable stage III non–small-cell lung cancer. By itself, thoracic radiotherapy provides local control and effective palliation of symptoms, but has a minimal effect on survival.[1-3] Novel schemes of radiation such as hyperfractionated radiation[4] and conti...

Combined chemotherapy and radiation therapy have started to replace the traditional local approach of thoracic radiotherapy alone for unresectable stage III non–small-cell lung cancer. By itself, thoracic radiotherapy provides local control and effective palliation of symptoms, but has a minimal effect on survival.[1-3] Novel schemes of radiation such as hyperfractionated radiation[4] and conti...

Radiotherapy offers an alternative to steroid therapy for idiopathic inflammatory orbital pseudotumours. Twenty-four orbits were treated with radiotherapy, of which 75% responded adequately. There were no significant complications and no recurrences during the average follow-up time of 22.3 months (1-50 months). Biopsy, CT scanning, and steroid response of orbital pseudotumours can be helpful i...

PURPOSE This study tested the hypothesis that the type of dose fractionation regimen determines the ability of radiotherapy to synergize with anti-CTLA-4 antibody. EXPERIMENTAL DESIGN TSA mouse breast carcinoma cells were injected s.c. into syngeneic mice at two separate sites, defined as a "primary" site that was irradiated and a "secondary" site outside the radiotherapy field. When both tum...

Multiple arc or multiple field convergent beam irradiation techniques have been used extensively for stereotactic radiosurgery (SRS) or radiotherapy (SRT) of small lesions. A major problem is that dose distributions produced by employing rectangular or circular collimators are of simple convex shape and therefore do not allow conformal treatment of irregularly shaped lesions. The use of multipl...

To achieve tumor control for radiotherapy, a dose distribution is planned which has a good chance of sterilizing all cancer cells without causing unacceptable normal tissue complications. The aim of the present study was to achieve an accurate calculation of dose for small field dimensions and perform this by evaluating the accuracy of planning system calculation. This will be compared with rea...

The purpose of this study was to explore how radiologist and oncologists may work together efficiently and effectively to define target volume for radiotherapy treatment. Ten patients were chosen at random from those needing radiotherapy between December 2004 and June 2005. Sites of primary cancer included head and neck, pelvis, lung and brain. Diagnostic scans were available on the hospital PA...

Introduction: Irregular/blocked fields are routinely used in radiotherapy. The doses of these fields are usually calculated by means of equivalent square method that is inherently prone to uncertainty. On the other hand, Clarkson’s sector integration method is a dose calculation method which offers far better accuracy in dose calculation of irregular fields. The Scatter Air Ratio (SAR) of an in...