Antibiotic resistance is threatening to make gonorrhoea untreatable. Point-of-care (POC) tests that detect resistance promise individually tailored treatment, but might lead to more treatment and higher levels of resistance. We investigate the impact of POC tests on antibiotic-resistant gonorrhoea. We used data about the prevalence and incidence of gonorrhoea in men who have sex with men (MSM) ...

The integration of segregated brain functional modules is a prerequisite for conscious awareness during wakeful rest. Here, we test the hypothesis that temporal integration, measured as long-term memory in the history of neural activity, is another important quality underlying conscious awareness. For this aim, we study the temporal memory of blood oxygen level-dependent signals across the huma...

In this work we devise a classification of mouse activity patterns based on accelerometer data using Detrended Fluctuation Analysis. We use two characteristic mouse behavioural states as benchmarks in this study: waking in free activity and slowwave sleep (SWS). In both situations we find roughly the same pattern: for short time intervals we observe high correlation in activity--a typical 1/f c...

Rats repeatedly ran through a sequence of spatial receptive fields of hippocampal CA1 place cells in a fixed temporal order. A novel combinatorial decoding method reveals that these neurons repeatedly fired in precisely this order in long sequences involving four or more cells during slow wave sleep (SWS) immediately following, but not preceding, the experience. The SWS sequences occurred inter...

the capability to preserve human oocytes, blastocysts, ovarian tissue and spermatozoa is an important tool in human assisted reproductive techniques. this preservation allows patients undergoing chemotherapy or radiotherapy to preserve their fertility, and helps to attain all benefits from the costly ovarian superovulation therapies prior to art. the primary goal in establishing an appropriate ...

Leaf habit has been hypothesized to define a linkage between the slow-fast plant economic spectrum and drought resistance-avoidance trade-off in tropical forests (‘slow-safe vs fast-risky’). However, variation hydraulic traits as function of leaf rarely explored for large number species. We sampled branch functional 97 dry forest tree species from four sites investigate whether patterns trait v...

slow sand filters are as a proper technology for pre-treatment of raw water, with a fine and medium trubidity in small communities in developing countries. thus, with a minimum operation cost and minimum need for expest bodies have the maximum efficiency. the purpose of this research is carried out to evaluate the efficiency of two processes of horizontal flow roughing filter and vertical flow ...

objective(s): previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. the aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. materials and methods: four weeks after surgeries (left anterior descending (lad) artery occlusion), chr...

The physiological role of the muscle histidyl dipeptides carnosine and anserine in contractile function of various types of muscle fibers in vivo is poorly understood. Ten adult male Wistar rats were randomly assigned to two groups: control and supplemented for 10 wk with beta-alanine, the precursor of carnosine (∼640 mg·kg body wt(-1)·day(-1)). Thereafter, contractile properties and fatigabili...

Background HLA alleles are associated with differential outcomes of infections/diseases. We hypothesize that epitopes that interact with HLA alleles associated with resistance elicit a protective immune response in the host, and could therefore serve as good vaccine candidates. Among the HLA alleles reported to be associated with resistance to HIV infection/slow progression to AIDS, HLA-A*0201 ...