Kubota, Takeshi, Jidong Fang, Zhiwei Guan, Richard A. Brown, and James M. Krueger. Vagotomy attenuates tumor necrosis factor-a-induced sleep and EEG d-activity in rats. Am J Physiol Regulatory Integrative Comp Physiol 280: R1213–R1220, 2001.—Much evidence suggests that tumor necrosis factor-a (TNF-a) is involved in the regulation of physiological sleep. However, it remains unclear whether perip...

PURPOSE OF REVIEW This article summarizes the clinical and electrophysiologic manifestations of nocturnal seizures, particularly nocturnal frontal lobe epilepsy (NFLE), parasomnias, and other disorders presenting with complex behaviors in sleep. The evaluation and treatment of patients with complex nocturnal behaviors can be challenging. While the differential diagnosis of sleep-related movemen...

Electroencephalography (EEG) recordings after sleep deprivation increase the diagnostic yield in patients suspected of epilepsy if the routine EEG remains inconclusive. Sleep deprivation is associated with increased interictal EEG abnormalities in patients with epilepsy, but the exact mechanism is unknown. In this feasibility study, we used a network analytical approach to provide novel insight...

The human sleep EEG is studied using a dynamical system approach to the sleeping brain. The dynamics of the sleeping brain is governed by multiple time scales: ranging from the typical EEG oscillations at 1 − 30 Hz up to the ≈ 24h circadian rhythm. Starting point is the fastest time scale the sleep oscillations. They are described by modeling the EEG using adaptive linear models. The slower dyn...

The effects of various cholinergic agonists and antagonists and their interactions were determined on the awake-sleep cycle of cats with chronic indwelling brain electrodes. The effects were measured by the use of the EEG and correlated with gross behavioral observation. EEG recordinxs were taken from various neocortical and limbic structures, ~cluding the amygdala and hi~pocampus. EEG activati...

The aim of the study was to investigate whether the electromagnetic field (EMF) emitted by digital radiotelephone handsets affects brain physiology. Healthy, young male subjects were exposed for 30 min to EMF (900 MHz; spatial peak specific absorption rate 1 W/kg) during the waking period preceding sleep. Compared with the control condition with sham exposure, spectral power of the EEG in non-r...

Photoperiod influences the distribution of sleep and waking and electroencephalogram (EEG) power density in the Djungarian hamster. In an experimental procedure combining short photoperiod (SP) and low ambient temperature, the light-dark difference in the amount of sleep was decreased, and the changes in slow-wave activity (SWA) (mean EEG power density between 0.75 and 4.0 Hz) in nonrapid eye m...

Sepsis is a systemic immune response to infection that may result in multiple organ failure and death. Polymicrobial infections remain a serious clinical problem, and in the hospital, sepsis is the number-one noncardiac killer. Although the central nervous system may be one of the first systems affected, relatively little effort has been made to determine the impact of sepsis on the brain. In t...

STUDY OBJECTIVES Sleep-wake disturbances are often reported in Prader-Willi syndrome (PWS), a rare neurodevelopmental syndrome that is associated with paternally-expressed genomic imprinting defects within the human chromosome region 15q11-13. One of the candidate genes, prevalently expressed in the brain, is the small nucleolar ribonucleic acid-116 (SNORD116). Here we conducted a translational...

The baseline EEG sleep patterns of 10 young depressed patients, 20 patients with anorexia nervosa, 10 patients with bulimia nervosa, and 10 healthy subjects were found to be indistinguishable, except for an increased REM density in the depressed patients. In eating disorder patients, a concomitant major depressive episode had no influence on EEG sleep. The results of the cholinergic REM sleep i...