A screen for Drosophila synaptic dysfunction mutants identified slug-a-bed (slab). The slab gene encodes ceramidase, a central enzyme in sphingolipid metabolism and regulation. Sphingolipids are major constituents of lipid rafts, membrane domains with roles in vesicle trafficking, and signaling pathways. Null slab mutants arrest as fully developed embryos with severely reduced movement. The SLA...

Reducing the settlements of soft foundation effectively is a critical problem of high-speed railway construction in China. The new CFG pile-slab structure composite foundation is a ground treatment technique which is applied on CFG pile foundation and pile-slab structure composite foundation. Based on the experience of constructing Beijing-Shanghai high-speed railway in China, the settlement-co...

Experimental demonstrations of two edge-pumped zigzag slab lasers are presented. The Nd:YAG slab laser generated 127 W of multimode output power with 300W of pump power. Preliminary results with a Yb:YAG slab produced 46 W of output power with 315W of pump power. The edge-pumped slab design permits symmetric conduction cooling and efficient pump absorption and accepts large-numerical-aperture p...

We show that a new subduction zone can initiate at a preexisting dipping fault zone with reasonable plate forces, consistent with what is observed in the western Pacific. The dynamics of subduction initiation within a viscoelastic medium has been systematically explored with the finite element method. We investigate the compression of oceanic lithosphere with hoth force and velocity boundary co...

Wireless Sensor Networks constitute pervasive and distributed computing systems and are potentially one of the most important technologies of this century. They have been specifically identified as a good candidate to become an integral part of the protection of critical infrastructures. In this paper we focus on railway infrastructure protection and we present the details of a sensor platform ...

• Geosynthetic Reinforced Soil with Retaining Wall (GRS-RW) vs conventional embankment. The experiments are carried out in a full-scale testing facility laboratory. Two track forms considered: three-sleeper concrete slab and ballasted track. GRS-RW structure showed good performance under both static cyclic loading. pressure levels found the experiment were compared against literature. This pape...

Methods of preparing test specimens in laboratories are particularly important. It also holds true in terms of compaction procedure in predicting pavement performance. The currently available laboratory compactor cannot adequately replicate field compaction conditions, especially the Stone Mastic Asphalt (SMA) mixture. The essential element of SMA mixture comprises of stones that are placed nex...

The main design criteria of ballasted railway tracks include rail deflections, rail bending stresses, rail wheel contact stresses, sleeper bending moments and ballast sleeper contact pressures. Numerous criteria have been defined for the design of ballasted railway tracks owing to the various mechanical properties of track components and their complex interaction. Therefore, railway track desig...

Abstract The current paper considers and summarize the elaborated inspection of existing condition operational capacity structure a tunnel beneath National Palace Culture together with collected data conclusion concerning top slab to undertake an additional load from secondary track light rail load. It also includes assessment durability compliance regulation requirements. report - review analy...