Duchenne muscular dystophy (DMD) is a severe muscle wasting disease caused by mutations in the dystrophin gene. By utilizing antisense oligonucleotides, splicing of the dystrophin transcript can be altered so that exons harbouring a mutation are excluded from the mature mRNA. Although this approach has been shown to be effective to restore partially functional dystrophin protein, the level of d...

Background: Antisense-mediated exon skipping is currently one of the most promising therapeutic approaches for Duchenne muscular dystrophy (DMD). Using antisense oligonucleotides (AONs) targeting specific exons the DMD reading frame is restored and partially functional dystrophins are produced. Following proof of concept in cultured muscle cells from patients with various deletions and point mu...

Rope skipping is an effective way of training. In this study, we concentrated on the rope skipping exercise of using the equipment without a rope which is called “air jump rope”. We have developed a system for recognizing the rotational motion of the rope skipping exercise. The system analyses a motion of jumping rope using the moving image processing using the IR camera of Microsoft Kinect. By...

OBJECTIVES To assess the potential nutritional contribution of meals provided in a sample of community programmes for homeless individuals, to determine the effect of food donations on meal quality and to develop food-based guidance for meals that would meet adults' total nutrient needs. SETTING Toronto, Canada. DESIGN An analysis of weighed meal records from eighteen programmes. The energy...

A bstract We clarify general mathematical and physical properties of pole-skipping points. For this purpose, we analyse scalar vector fields in hyperbolic space. This setup is chosen because it simple enough to allow us obtain analytical expressions for the Green’s function check everything explicitly, while contains all essential features classify points three types (type-I, II, III). Type-I T...

The launch-site effect, a systematic variation of within-word landing position as a function of launch-site distance, is among the most important oculomotor phenomena in reading. Here we show that the launch-site effect is strongly modulated in word skipping, a finding which is inconsistent with the view that the launch-site effect is caused by a saccadic-range error. We observe that distributi...