The major concanavalin A-binding component in urea/deoxycholate/mercaptoethanol extracts of pig skin was a collagenous disulphide-cross-linked glycopolypeptide with an apparent molecular mass of 150 kDa and a pI of 5.5. Antiserum against the electrophoretically purified glycopolypeptide gave strong dermal staining similar to that seen with fluorescent concanavalin A. Immunocytochemical labellin...

the topical delivery of non-steroidal anti-inflammatory drugs (nsaids) such as ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. however, it is dif...

A 52-year-old woman sought medical attention because of several annular erythematous lesions with central clearing on her body since seven months ago. No pruritus or burning sensations were noted. Her medical and family history was unremarkable. Her Fitzpatrick skin photo-type was II. On dermatological physical examination, there were several annular erythematous plaques with raised borders and...

introduction: glabrous skin and hairy skin are innervated by different types of noxious fibers. however, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. methods: in this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into ...

background: practice of interventional cardiology procedures such as coronary angiography (ca) and percutaneous transluminal coronary angioplasty (ptca) has largely increased in recent years and is now changing to a matter of routine in many hospitals. the purpose of this study was to measure skin and organ doses in patients undergoing ca and ptca and to find a probable relation with cardiologi...

BACKGROUND Minimal erythemal dose (MED) for narrow band-ultraviolet B radiation (NB-UVB) varies with race and skin type. The aim was to estimate the MED for NB-UVB and compare visual readings with those from a Dermaspectrometer in a north Indian patients as the available data is sparse. METHODS Forty one patients who visited the dermatology outpatient department were recruited for this study....

Gene expression profiling of the blood cell response induced early after vaccination has previously been demonstrated to predict the immunogenicity of vaccines. In this study, we evaluated whether the analysis of the gene expression profile of skin-migrated dendritic cells (DCs) could be informative for the in vitro prediction of immunogenicity of vaccine, using canine adenovirus serotype 2 (CA...