Tuberculosis is still one of the major global public health threats. Countries with low incidence must focus on exhausting the reservoir of future cases by preventing reactivation. Therefore, it is important to identify and effectively treat those individuals who have latent tuberculosis infection and who may develop active disease. The tuberculin skin test has been the standard for detection o...

BACKGROUND Preventive therapy for tuberculosis in patients with HIV is effective, but it has not been widely implemented in moderate or high-burden settings. We assessed the effect of widespread use of isoniazid preventive therapy on rates of tuberculosis and death in people with HIV in Brazil. METHODS We did a stepped wedge, cluster-randomised trial with patients actively enrolled in 29 HIV ...

Background: Granulomatous dermatoses are common skin pathology, often need histopathological confirmation for diagnosis. Histologically six sub-types of granulomas found in granulomatous skin diseases- tuberculoid, sarcoidal, necrobiotic, suppurative, foreign body & histoid type. The aims of the present study were clinico-pathological evaluation of granulomatous skin l...

Erythema induratum of Bazin (EIB) is a rare skin form tuberculosis (TB) that most commonly seen in middle-aged women. Clinically, EIB can mimic several conditions, which often leads to delay diagnosis. We report here the observation new case EIB, presenting as chronic nodular panniculitis, 38-year-old female patient..

OBJECTIVES To evaluate the efficacy of isoniazid for the prevention of tuberculosis in tuberculin skin test-positive and negative individuals with HIV infection. DESIGN Meta-analysis of randomized controlled trials. SETTING Seven trials from Mexico, Haiti, the United States, Zambia, Uganda and Kenya. PATIENTS Individuals free from tuberculosis, 2367 persons in the intervention and 2162 in...

www.thelancet.com/respiratory Published online January 31, 2017 http://dx.doi.org/10.1016/S2213-2600(17)30012-7 1 The UN Sustainable Development Goals have led to global plans to end the tuberculosis epidemic. Individuals with latent tuberculosis infection are at risk of reactivation disease and onward transmission to contacts. Identifi cation of these people before they develop active tubercul...

Introduction: Tuberculosis remains a public health problem worldwide. The BCG vaccination is one of response means. objective this work was to study impact on morbidity and mortality related childhood tuberculosis in Niamey. Patients methods: It multicenter prospective comparative from January September 2017 two-referral hospital centers Niamey the National Anti-Tuberculosis Center. population ...

Background: Appropriate diagnosis and treatment of latent tuberculosis infection (LTBI) play the most important role in the control of tuberculosis. This study aimed to determine the prevalence of LTBI among healthy tuberculosis unexposed children vaccinated with BCG using the tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube (QFT-GIT) and comparing the agreement between the two tests....

Tuberculosis is a chronic granulomatous disease that can affect various systems of the body. It is caused mainly by Mycobacterium tuberculosis, Mycobacterium bovis and other atypical mycobacterial species[1]. Pulmonary tuberculosis is the most common primary form of the disease. However it can occur in lymph nodes, meninges, kidneys, bones, skin and the oral cavity. Secondary tuberculosis occur...