BACKGROUNDS AND OBJECTIVE Spinal cord injury remains to be a challenge to clinicians and it is attractive to employ autologous adult stem cell transplantation in its treatment, however, how to harvest cells with therapeutic potential easily and how to get enough number of cells for transplantation are challenging issues. In the present study, we aimed to isolate skin-derived precursors (SKPs) a...

Graft-versus-host disease (GVHD) is the most serious complication following bone marrow transplantation, with an incidence of 40-60%. The disease can be fatal in 50% of cases, even in patients receiving marrow from an HLA identical sibling. Several assays have been developed to try to predict the development of GVHD, including mixed lymphocyte culture reaction, cytotoxic T lymphocyte precursor,...

Immunohistological staining of skin from normal donors and bone marrow transplant recipients was undertaken using antibodies to two vessel associated adhesion molecules, endothelial leucocyte adhesion molecule-1 (ELAM-1). In normal skin ELAM-1 staining was restricted to a variable but generally small number of endothelial cells which were significantly increased in graft-versus-host disease (Gv...

Sir Peter Medawar experimentally demonstrated immunological tolerance through his tissue transplantation experiment in the early and mid-1950s. He made a central contribution to modern biomedicine by showing that genetically distinct cells introduced into a body during its foetal phase could not only be permanently tolerated but also make the host accept any subsequent skin grafts from the orig...

Sir Peter Medawar experimentally demonstrated immunological tolerance through his tissue transplantation experiment in the early and mid-1950s. He made a central contribution to modern biomedicine by showing that genetically distinct cells introduced into a body during its foetal phase could not only be permanently tolerated but also make the host accept any subsequent skin grafts from the orig...

Sir Peter Medawar experimentally demonstrated immunological tolerance through his tissue transplantation experiment in the early and mid-1950s. He made a central contribution to modern biomedicine by showing that genetically distinct cells introduced into a body during its foetal phase could not only be permanently tolerated but also make the host accept any subsequent skin grafts from the orig...

BACKGROUND Thromboangiitis obliterans, also known as Buerger's disease, is characterized by peripheral occlusive changes in the arteries of the upper and lower limbs and treatment is often ineffective. Intramuscular transplantation of autologous bone marrow-mononuclear cells (BM-MNC) has been recently reported as improving the symptoms and clinical manifestations in patients with severely ische...

Sir Peter Medawar experimentally demonstrated immunological tolerance through his tissue transplantation experiment in the early and mid-1950s. He made a central contribution to modern biomedicine by showing that genetically distinct cells introduced into a body during its foetal phase could not only be permanently tolerated but also make the host accept any subsequent skin grafts from the orig...

Sir Peter Medawar experimentally demonstrated immunological tolerance through his tissue transplantation experiment in the early and mid-1950s. He made a central contribution to modern biomedicine by showing that genetically distinct cells introduced into a body during its foetal phase could not only be permanently tolerated but also make the host accept any subsequent skin grafts from the orig...

Skin grafting has become a basic and established operation technique; however, it is not clear how skin grafts adapt to recipient beds and replace their functions. In this study, we analyzed the origin of cells in adapted transplants by using green fluorescent protein (GFP) transgenic mice, which emits green fluorescence in the whole body. The dorsal skins of GFP transgenic mice were transplant...