The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc.) producing reactive oxygen species (ROS) and physical damage (e.g., wounds, ...

Skin color has always been important and interest to people in all cultures. Disorders of skin color, either hyperor hypopigmentation are cosmetically vexing and can be signs of systemic disease. For many centuries physicians have tried to treat such disorders. We review some of the history of treatments for hyperpigmentation and the development of hydroquinone, currently the medication of choi...

BACKGROUND AND OBJECTIVES Because dermatologic complaints are encountered frequently in primary care, the education of family physicians about skin disorders is important. Data are needed to help define areas of dermatology that deserve the most time and emphasis. This study determined what types of skin problems and medications family physicians most commonly diagnose and prescribe. METHODS ...

In this report, we have summarized our 9-year experience of over 100 proven cases of lysosomal storage disease using electron microscopic evaluation of skin biopsies as a screening tool. The skin biopsy was very specific in establishing the diagnosis in only two disorders, namely neuronal ceroid lipofuscinosis and mucolipidosis IV. Although the biopsy was not diagnostic in other categories of s...

AIMS To quantify the risk of serious blood and skin disorders requiring hospitalization among otherwise healthy users of co-trimoxazole. METHODS We conducted a population-based cohort study at Group Health Cooperative of Puget Sound (GHC). RESULTS During the years 1987 to 1993 we found six cases of co-trimoxazole-associated blood disorders and three cases of co-trimoxazole-associated skin d...

The negative socioeconomic impact of mental health disorders and skin diseases has increased in part due to the conflict between Russia Ukraine, which been a fertile ground for emergence psychopathologies. It is firmly established that there direct thread etiopathogenetic communication neuropsychiatric disorders, literature tried reveal pathophysiological mechanisms governing such bidirectional...

Darier’s disease results from abnormal keratinization of skin and is characterized by numerous keratotic papules that preferentially involve seborrheic areas. Kaposi’s varicelliform eruption (KVE) occurs by viral infections such as herpes simplex virus (HSV) in some inflammatory skin disorders like Darier’s disease. Herein, we describe a 68-year-old man, a known case of Darier’s disease, who pr...

Introduction: In HIV infected children, skin disorders are important as they serve clue to diagnosis of the disease. The Skin is one early systems affected by HIV/AIDS, which can affect almost all organs and in body. Prevalence among children up 90% some studies. Objective: To determine prevalence attending paediatric infectious disease clinic Aminu Kano Teaching Hospital Kano, Nigeria. Materia...