Wound healing requires a complex series of reactions and interactions among cells and their mediators, resulting in an overlapping series of events including coagulation, inflammation, epithelialization, formation of granulation tissue, matrix and scar formation. Cytokines and chemokines promote inflammation, angiogenesis, facilitate the passage of leukocytes from circulation into the tissue, a...

BACKGROUND The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion and proliferation of P. aeruginosa within the burn wound and reduce mortality. METHODS Thermal injuries were induced in anesthetized mice, and P. aeruginosa was applied to th...

background different methods for dressing of donor site of skin graft in burn patients have similarly pain, limitation of mobility of donor site and local complications such as infection and scar. amniotic membrane has used for improvement of healing in some wounds. accordingly in this study amnion was used as biologic dressing for donor site of skin graft to evaluate it’s efficacy in improveme...

INTRODUCTION Negative Pressure Wound Therapy (NPWT) has proven to be a powerful tool in facilitating healing of difficult wounds of a variety of etiologies. The pediatric experience with NPWT has been limited due to concerns about vascular compression and pain associated with treatment. METHOD A retrospective review was performed to evaluate the therapeutic effect of NPWT on children with dif...

BACKGROUND Nanoemulsions are broadly antimicrobial oil-in-water emulsions containing nanometer-sized droplets stabilized with surfactants. We hypothesize that topical application of a nanoemulsion compound (NB-201) can attenuate burn wound infection. In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following therm...

BACKGROUND Skin burn is one of the most common complications and remains a major public health issue worldwide. OBJECTIVES This experiment was conducted to study the effects of traditional medicine (Visceral Fat and Barely Seed Ash) compared with silversulfadiazine (SSD) cream on healing burn wounds in rats. MATERIALS AND METHODS Sixty adult male Wistar rats were randomly divided into four ...

Background Burn injury is a significant problem that affects approximately half a million people in the U.S. annually. One of the major complications emerging from burn injury is hyperglycemia, which can last for weeks following the initial trauma. Current therapeutic methods include tight euglycemic control and insulin treatment, which are associated with increases in hypoglycemia and mortalit...

New skin substitutes for burn medicine or reconstructive surgery pose an important issue in plastic surgery. Matriderm® is a clinically approved three-dimensional bovine collagen-elastin matrix which is already used as a dermal substitute of full thickness burn wounds. The drawback of an avital matrix is the limited integration in full thickness skin defects, depending on the defect size. To fu...

Chilldren/adults with severe burn wounds often endure uncontrolled pain during wound care. Bandages are changed, and wounds cleaned frequently to prevent infection. Physical therapy skin stretching exercises can also be painful. Immersive virtual reality is proving valuable as an adjunctive non-pharmacologic analgesic. Patients “go into” the computer generated world to escape their pain. Result...

The increasing trend in the occurrence of antibiotic resistance for Pseudomonas aeruginosa (a hostile bacterium growing on skin wounds especially those as a result of burn and leading to infectious conditions) has been accompanied with numerous complications and can even lead to septicemia and mortality. The spread of skin infections, especially those as a result of resistant variants of Pseudo...