The anabolic effect of estrogen on epidermis stimulates cell differentiation. It increases mitotic activity in the stratum basale and the stratum spinosum. The effect of estrogen on keratinocytes runs via interposed growth factors. The insulin-like growth factor (IGF-I) is mostly significant: fibroblasts in the epidermis are stimulated to set free IGF-I, the latter stimulating the growth of epi...

BACKGROUND Natural products made from plant sources have been used in a variety of cosmetic applications as a source of nutrition and as a whitening agent. The flowers of Cassia fistula L, family Fabaceae, have been used as a traditional medicine for skin diseases and wound healing and have been reported to possess anti-oxidant properties. The anti-aging effect of C. fistula flower extract on h...

Skin aging is a natural process, which consists in reducing the biological activity of body’s cells, slowing down regenerative processes and loss of adaptability. The decisive role is played by genetic factors and associated with them external factors, such as: UV radiation, environmental pollution, smoking, improper care and internal factors connected with hormonal regulation disorders, poor n...

We propose a layered facial simulation model for skin aging with wrinkles, which includes muscle, connective tissue and skin layer. Our aim is to simulate relevant facial animation and aging with the guidance of general facial tissue anatomy, so that the model can be extended to medical and cosmetic applications. B-spline muscle patches are automatically adapted to each individual face by mappi...

Our aging skin undergoes changes with reductions in collagenous and elastic fibers, fibroblasts, mast cells, and macrophages with free radical production, which can result in reduced skin tone and wrinkle formation. Fibroblasts are important for dermal integrity and function with a decrease in function producing less skin tone, thinning, and wrinkle formation. Dermal levels of adenosine triphos...

As the global population continues to age, aging research has become an important topic for achieving healthy and preventing age-related diseases. Aging of skin, largest organ body, is one major factors that reduce quality life in terms function appearance. Today, mitochondrial dysfunction known be hallmarks. Mitochondria are intracellular organelles primarily produce ATP. It generally accepted...

Since in vitro methods (2D and 3D) used for the preclinical testing of candidate anti-aging compounds mimic complexity human skin aging unsatisfactorily, we wished to develop an ex vivo assay interrogating key aging-read outs healthy skin. Healthy, full-thickness biopsies (2 males, 4x females; 22 - 77 years) were organ-cultured serum-free, supplemented medium 3 days presence/absence recognized ...

To find the new raw material having skin care activity, P. oleracea of organic native plant was extracted and concentrated with solvent extracting method. As a cosmetic active material, it is to develop an active raw molecule for discovering new skin pathway such as anti-aging, whitening and wrinkle skin improvement. The skin irritating evaluations (in-vitro) were performed to confirm the skin ...

Skin exfoliators, specifically alpha and beta hydroxy acids, have been shown to improve overall skin health the clinical signs of aging. A micropeeling cream was developed with acids a brown algae extract efficacy tolerability were evaluated in two parts. In first part pre-clinical investigation, placebo control by ELISA, immunostaining, qPCR an activity assay using ex vivo vitro models. second...

BACKGROUND Different clinical features of skin diseases have been addressed between aging patients and non-aging patients. However, data focusing on the clinical features of chronic urticaria (CU) in aging patients especially in the Asian population are still limited. OBJECTIVE This study aimed to investigate the clinical characteristics of CU in aging and non-aging patients in the Asian popu...