background prediction of skeletal growth is necessary for growth modification and surgical orthodontic treatments and is usually done by assessing skeletal maturity indicators in hand-wrist radiographs. the use of growth stages of cervical vertebrae in lateral cephalograms has been suggested to avoid overexposure. objectives this study seeks to assess the degree of agreement between hand-wrist ...

skeletal muscle is a highly differentiated tissue with very specific functions which has low potential of regeneration. skeletal muscle injuries especially in athletes almost have lead to muscular dysfunctions and healing may be prolonged for several years. therefore, working on skeletal muscle differentiation remained an importance in biomedical researches. adipose derived stem cells (adscs) a...

AIM This study is aimed at investigating the prevalence of disorders among patients referred to Tabriz Dental School in 2016. MATERIALS AND METHODS This research was conducted in a cross-section method and taken from all patients admitted during this period. Classification of dental occlusion in patients was based on Angle's definition, skeletal classification was based on Steiner's analysis,...

Skeletal muscle has great regenerative capacity which is dependent on muscle stem cells, also known as satellite cells. A loss of satellite cells and/or their function impairs skeletal muscle regeneration and leads to a loss of skeletal muscle power; therefore, the molecular mechanisms for maintaining satellite cells in a quiescent and undifferentiated state are of great interest in skeletal mu...

Skeletal muscle comprises approximately 40% of body weight, and is important for locomotion, as well as for metabolic homeostasis. Adult skeletal muscle mass is maintained by a fine balance between muscle protein synthesis and degradation. In response to cytokines, nutrients, and mechanical stimuli, skeletal muscle mass is increased (hypertrophy), whereas skeletal muscle mass is decreased (atro...

BACKGROUND MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ~22 nucleotides in length. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) of their regulatory target mRNAs. Recent work has begun to reveal roles for miRNAs in a wide range of biological processes, including cell proliferation, differentiation and ap...

Saturated free fatty acids (FFAs) act as lipid mediators and induce insulin resistance in skeletal muscle. Specifically, in obesity-related diseases such as type 2 diabetes, FFAs directly reduce insulin sensitivity and glucose uptake in skeletal muscle. However, the knowledge of how FFAs mediate inflammation and subsequent tissue disorders, including fibrosis in skeletal muscle, is limited. FFA...

OBJECTIVE Chronic kidney disease-mineral and bone disorders (CKD-MBDs) are a spectrum of abnormalities involving skeletal hormones, minerals, and bone turnover and mineralization. This paper focuses on what the endocrinologist should know about the assessment and management of skeletal and metabolic disorders in CKD-MBDs. METHODS Relevant literature was reviewed to (1) define disturbances of ...

Congenital skeletal anomalies are rare disorders, with a subset affecting both the cranial and appendicular skeleton. Two categories, craniosynostosis syndromes and chondrodysplasias, frequently result from aberrant regulation of the fibroblast growth factor (FGF) signaling pathway. Our recent work has implicated FGF signaling in a third category: ciliopathic skeletal dysplasias. In this work, ...

Mutations in RYR1 encoding the ryanodine receptor (RyR) skeletal muscle isoform (RyR1) are a common cause of inherited neuromuscular disorders. Despite its expression wide range tissues, non-skeletal manifestations associated with mutations have only been rarely reported.Here, we report three patients diagnosis Central Core Disease (CCD), King-Denborough Syndrome (KDS) and Malignant Hyperthermi...