Currently, no pharmacological therapies treat skeletal muscle insulin resistance in pathological conditions such as type 2 diabetes, age-associated diseases, and cancer. Therefore, there is an unmet need to identify the molecular mechanisms ...The events governing glucose uptake have potential for managing obesity, With current treatments target ...

A hospital based study of skeletal dysplasias was conducted over a period of 2 years in Davangere, Karnataka, in which 169 cases of skeletal dysplasias were studied. One hundred were osteochondrodysplasias and were grouped according to international classification of osteochondrodysplasias. Among the individual cases, osteogenesis imperfecta (13 cases) had the maximum representation. Several ca...

fasting induces short-term physiological adaptations which spare the body's remaining carbohydrate stores and mobilize lipid stores to provide a substitute fuel for many tissues and organs, especially skeletal muscle. rodent studies show that regular occurrence of fasting then refeeding, stimulates adaptations in muscle which make the animal better placed to withstand a further period of fastin...

retinoic acid (ra) plays a key role in pattern formation along the major body axis and limbformation during vertebrate development. exposure to excessive retinoic acid (in uterus) generatescongenital malformations in limbs, craniofacial, cns, urogenital, heart, and axial skeletons. in thesestudies, seven groups of nmri pregnant mice were administered a single gavage dose of 100 mg /kgbody weigh...

introduction: satellite cells are known as the main regenerative cell type in skeletal muscles. our study established a modified digestion and preplating method for the isolation of slow or weak adherent cells for the enrichment of satellite cells. low-survival rate of these primary stem cells prompted us to address whether cell culture medium substitution might change cell viability status. me...

background: the purpose of present study was to investigate whether sphingosine 1-phosphate (s1p) levels and its receptors gene expressions are correlated with myod and myogenin following resistance training. materials and methods: 24 eight-week-old male wistar rats (190-250 gr) were assigned randomly to a control (n = 12) or training (n = 12) group. rats climbed a resistance training ladder wi...

The skeletal age on the basis of the diaphyseal length of long bones was assessed. To this aim a sample of subadults skeleton, dated to last century, coming from the cemetery of Bologna was studied. The sample is composed by 79 males and 70 females between 0 and 12 years, whose chronological age and sex are known. Some information can be obtained by the means, standard deviation and graphs of t...

OBJECTIVE The aim of this study is to evaluate dentoskeletal effects of Herbst and Twin Block (TB) appliance therapies in Skeletal Class II malocclusion. SUBJECTS AND METHODS Herbst group consisted of 11 girls and 9 boys (mean age = 12.74 ± 1.43 years), TB group comprised of 10 girls and 10 boys (mean age = 13.0 ± 1.32 years), and control group included 9 girls and 11 boys (mean age = 12.17 ±...

In laboratory rodents, caloric restriction (CR) retards several age-dependent physiological and biochemical changes in skeletal muscle, including increased steady-state levels of oxidative damage to lipids, DNA, and proteins. We used immunogold electron microscopic (EM) techniques with antibodies raised against 4-hydroxy-2-nonenal (HNE) -modified proteins, dinitrophenol, and nitrotyrosine to qu...