We conduct genetic association analysis in the subset of unrelated individuals from the San Antonio Family Studies pedigrees, applying a two-stage approach to take account of the dependence between systolic and diastolic blood pressure (SBP and DBP). In the first stage, we adjust blood pressure for the effects of age, sex, smoking, and use of antihypertensive medication based on a novel modific...

Hypertension is a significant cause of morbidity and mortality worldwide. It is defined as systolic and diastolic blood pressures (SBP/DBP) >140 and 90 mmHg, respectively. Individuals with an SBP between 120 and 139, or DBP between 80 and 89 mmHg, are said to exhibit pre-hypertension. Hypertension can have primary or secondary causes. Primary or essential hypertension is a multifactorial diseas...

BACKGROUND In patients with type 2 diabetes, the prognostic impact of an orthostatic rise in blood pressure is not known. Therefore, the aim of this study was to determine the prognostic implications of the diastolic orthostatic blood pressure response in a cohort of patients with type 2 diabetes. We also evaluated associations between different orthostatic blood pressure responses and markers ...

patients and methods in a double-blind clinical trial, 103 patients (american society of anesthesiologists class i, ii) aged 18 - 45 years old, who were septorhinoplasty candidates, were randomly assigned into two groups, a 900 mg gabapentin group and placebo, in amir-al-momenin academic hospital. the drug was prescribed to the patients orally, 2 hours before the operation. anesthetic technique...

BACKGROUND Racial/ethnic differences in the associations of smoking with uncontrolled blood pressure (BP) and its subtypes (isolated uncontrolled systolic BP (SBP), uncontrolled systolic-diastolic BP, and isolated uncontrolled diastolic BP (DBP)) have not been investigated among diagnosed hypertensive subjects. METHODS A sample of 7,586 hypertensive patients aged ≥18 years were selected from ...

OBJECTIVES The goal of this study was to evaluate the role of diastolic blood pressure (DBP) in cardiovascular mortality for different systolic blood pressure (SBP) levels in middle-aged men and women. BACKGROUND In middle-aged subjects it is unclear whether DBP, in addition to SBP, should be considered for risk evaluation. METHODS Subjects (77,023 men; 48,480 women) aged 40 to 70 years old...

BACKGROUND To compare the effect of bimatoprost and the fixed combination latanoprost-timolol (LTFC) on 24-hour systolic (SBP) and diastolic (DBP) blood pressure and on 24-hour ocular perfusion pressure (OPP). METHODS 200 patients with glaucoma or ocular hypertension, controlled on the unfixed combination of latanoprost and timolol or eligible for dual therapy being not being fully controlled...

This study aimed to examine the effects of inbreeding on 12 quantitative phenotypes like body weight, height, sitting height, head circumference, head length, head breadth, chest circumference, verbal, performance and full scale intelligence quotients, systolic and diastolic blood pressures among North Indian Children. The sample consisted of 3,253 subjects (1,683 males and 1,570 females) inclu...

Aim: To investigate the relation between change in systemic blood pressures and change in intraocular pressure. Methods: This was a population based study of people 43– 86 years old living in Beaver Dam, Wisconsin. Measurements at baseline (1988–90) and 5 year follow up of systemic blood pressures, intraocular pressures, and history of use of blood pressure medications. Results: Intraocular pre...