A maximum likelihood framework for estimating site-specific substitution rates is presented that does not require any prior assumptions about the rate distribution. We show that, when the branching pattern of the underlying tree is known, the analysis of pairs of positions is sufficient to estimate site-specific rates. In the abscense of a known topology, we introduce an iterative procedure to ...

This paper describes work carried out to develop a method for considering actual traffic loads during bridge evaluation. This method is based on the use of load correction factors which have been determined using a probabilistic analysis of bridge loads and resistance. Load correction factors are selected as a function of site characteristics and used in order to modify load effects calculated ...

Integration, excision, and inversion of defined DNA segments commonly occur through site-specific recombination, a process of DNA breakage and reunion that requires no DNA synthesis or high-energy cofactor. Virtually all identified site-specific recombinases fall into one of just two families, the tyrosine recombinases and the serine recombinases, named after the amino acid residue that forms a...

Health care providers are more likely to follow a clinical guideline if the guideline's recommendations are consistent with the way in which their organization does its work. Unfortunately, developing guidelines that are specific to an organization is expensive, and limits the ability to share guidelines among different institutions. We describe a methodology that separates the site-independent...

Photo-induced artificial RNA editing was demonstrated using photo-reactive oligonucleotides containing 3-cyanovinylcarbazole nucleoside. This non-enzymatic and sequence-specific methodology will make a major contribution to the elucidation of RNA functions including non-coding RNAs and to the development of drugs based on sequence-specific RNA editing.

Recorded ground motions in near fault region have completely distinct nature from others that recorded in far field of the fault. Near source outcomes cause much of the seismic energy to appear in a single large and long period pulse at the beginning of the velocity record. Assaluyeh complex is located near the reverse Assaluyeh fault that is a segment of Mountain Front Fault. This complex cont...