Cholesterol homeostasis is crucial for cellular function and organismal health. The key regulator for the cholesterol biosynthesis is sterol-regulatory element binding protein (SREBP)-2. The biochemical process and physiological function of SREBP-2 have been well characterized; however, it is not clear how this gene is epigenetically regulated. Here we have identified sirtuin (Sirt)6 as a criti...

A series of 7,12-dihydroindolo[3,2-d][1]benzazepine-6(5H)-ones (paullones) substituted at C9/C10 (Br) and C2 (Me, CF(3), CO(2)Me) have been synthesized by a one-pot Suzuki-Miyaura cross-coupling of an o-aminoarylboronic acid and methyl 2-iodoindoleacetate followed by intramolecular amide formation. Other approaches to the paullone scaffold based on Pd-catalyzed C-H activation were unsuccessful....

We give a detailed study of the semiconvergence behavior of projected nonstationary simultaneous iterative reconstruction technique (SIRT) algorithms, including the projected Landweber algorithm. We also consider the use of a relaxation parameter strategy, proposed recently for the standard algorithms, for controlling the semiconvergence of the projected algorithms. We demonstrate the semiconve...

PURPOSE Selective Internal Radiation Therapy (SIRT) with 90yttrium (Y-90) is an increasingly used therapeutic option for unresectable liver malignancies. Nontarget embolization of extrahepatic tissue secondary to vascular shunting can lead to SIRT associated complications. Our aim was to assess whether extrahepatic shunts can reliably be diagnosed based on hepatic digital subtraction angiograph...

PURPOSE The purpose of this study is to evaluate the radiation dose in patients undergoing liver angiographic procedure and verify the usefulness of different dose measurements to prevent deterministic effects. Gafchromic film, MicroMOSFET data and DIAMENTOR device of the X-ray system were used to characterize the examined interventional radiology (IR) procedure. MATERIALS AND METHODS A liver...

Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism. Methods: KK-Ay mice were used to validate the effects of MGF on lipid metabolic disorders. Liver biochemical indi...

Introduction: The SYS-CAPLIOX trial uses an implantable vascular access device (AVAS®) for repeated liver isolation intra-arterial oxaliplatin (LIOX) patients with inoperable colorectal cancer metastases (CRCLM). Similar to selective internal radiation therapy (SIRT), transarterial chemoembolization (TACE) and hepatic arterial infusion (HAI), the LIOX technique negates puncture has reduced surg...

Measuring and modeling patient quality of life is critically important in the evaluation cost-effectiveness any health intervention, with arguably being most consideration patients for whom a meaningful extension not feasible. In present study, we aimed to identify cost-utility analyses comparing selective internal radiation therapy (SIRT) systemic unresectable hepatocellular carcinoma (HCC) co...

Le bassin rennais est majoritairement constitué de terrains briovériens, schisteux, fracturés et présentant des degrés d’altération variables. Briovérienpeut être recouvert par formations superficielles quelques intrusions magmatiques sont injectées dans les plus anciens. Les matériaux rencontrés ont une faible résistance mécanique qui classe en SIRT (Sols indurés Roches tendres). Pendant plusi...