To verify that apoptosis is one of the possible mechanisms of neonatal vascular remodeling during the transition from fetal to neonatal circulation, we assayed for apoptosis and evaluated the expression of apoptosis-regulatory proteins in umbilical vessel versus ascending aorta, ductus arteriosus (DA) versus adjacent pulmonary artery and aorta, or aorta versus its branching arteries. Twenty-two...

OBJECTIVE To assess the diagnostic power of the umbilical venous-arterial index (VAI) for the prediction of poor fetal outcome. SUBJECTS AND METHODS This was a retrospective, cross-sectional clinical study in which normalized umbilical vein blood volume flow rate (nUV) (mL/min/kg estimated body weight), umbilical artery pulsatility index (UAPI), the newly developed VAI (nUV/UAPI), and the ute...

Bryan, E. M., and Kohler, H. G. (1975). Archives of Disease in Childhood, 50, 714. The missing umbilical artery. II. Paediatric follow-up. Of 143 infants with single umbilical artery detected by routine examination of the placenta, 25 had major malformations at birth; 3 of these survive. Another 6 were stillborn and 2 died during the first year of life. At follow-up 14 children could not be tra...

OBJECTIVE To develop national guidelines on the use of fetal Doppler in obstetrics. OPTIONS Whether umbilical cord artery, umbilical cord venous, ductus venosus, and middle cerebral artery Doppler are useful in assessing fetal health. OUTCOME Prediction of adverse perinatal outcome or prediction of fetal anemia. EVIDENCE MEDLINE search and review of bibliographies in identified articles. ...

BACKGROUND The aim of the study was to evaluate the relation between maternal placental Doppler velocimetry, levels of the maternal glucose, and clinical signs of vasculopathy in pregnancy complicated by pregestational diabetes mellitus. METHODS AND RESULTS A retrospective study of 155 pregestational diabetic women between the 22nd and 40th weeks of pregnancy, categorized in White classificat...