Acetyl-coenzyme A carboxylase α (ACC-alpha) is considered as the key regulatory enzyme in fatty acid biosynthesis. ACC-alpha gene is located on Caprine chromosome 11 and is polymorphic in many goat breeds. In the current study, we aimed to find possible single nucleotide polymorphisms (SNPs) in the exon 1 region of the ACC-alpha gene in Iranian Mahabadi goat breed. Genomic DNA was extracted fro...

Differences in the baseline levels of serum cytokines or single-nucleotide polymorphisms (SNPs) cytokine genes may be useful to predict outcomes for patients being treated metastatic breast cancer. We have measured plasma and characterized individual SNPs IL-1RA, IL-1β, IL-2, IL-6 TNFα 130 with cancer high-dose chemotherapy. Patients were cyclophosphamide (Group 1, 74 patients) paclitaxel-conta...

The fall armyworm, Spodoptera frugiperda, is a polyphagous global pest with preference for gramineous crops such as corn, sorghum and pasture grasses. This species comprised of two morphologically identical but genetically distinct host strains known the corn rice strains, which can complicate management approaches. Two molecular markers are commonly used to differentiate between however, disco...

Abstract Background 25-Hydroxyvitamin D (Vit.D) levels associated with cardiovascular disease (CVD) may vary according to genetic variants in the vitamin receptor (VDR) gene. However, existing results are not conclusive Egyptian population, where diabetes mellitus is a common CVD risk factor. The purpose of study was evaluate role VDR polymorphism patients by studying association rs2228570 ( Fo...

The objective of this study was to investigate polymorphisms MASP2, TG5 and DQA1 genes using PCR-DNA sequencing in seventy Holstein, Brown Swiss dairy cows (35 each). Under complete aseptic condition, blood samples were collected from each animal into tubes containing disodium EDTA as an anticoagulant for DNA extraction. PCR carried out amplification 305-bp 545-bp TG5, 373-bp genes. assessment ...

OBJECTIVES To identify genetic variants associated with neuroticism by performing a meta-analysis of genome-wide association results based on 1000 Genomes imputation; to evaluate whether common genetic variants as assessed by single-nucleotide polymorphisms (SNPs) explain variation in neuroticism by estimating SNP-based heritability; and to examine whether SNPs that predict neuroticism also pre...

BACKGROUND A great amount of data has been accumulated on genetic variations in the human genome, but we still do not know much about how the genetic variations affect gene function. In particular, little is known about the distribution of nonsense polymorphisms in human genes despite their drastic effects on gene products. METHODOLOGY/PRINCIPAL FINDINGS To detect polymorphisms affecting gene...

This article contains data on the single nucleotide polymorphisms (SNPs) rs1137115, rs1801272 and rs28399433 rs4105144 in CYP2A6 associated to smoking related variables in Mexican Mestizo smokers (Pérez-Rubio et al., 2017) [1]. These SNPs were selected due to previous associations with other populations. Mexican Mestizo smokers were classified according their smoking pattern. A genetic associat...

A fragment end ligation-mediated PCR strategy was used to analyze the AscI pulsed-field gel electrophoresis patterns of Listeria monocytogenes epidemic clone II (ECII), which led to the identification of single-nucleotide polymorphisms (SNPs) in prophage regions that differentiated the two ECII outbreak clones. SNPs in prophages that differentiated the outbreak clones of ECIII and -IV were also...

We present the 1,991,830-bp complete genome sequence of Lactobacillus acidophilus strain La-14 (SD-5212). Comparative genomic analysis revealed 99.98% similarity overall to the L. acidophilus NCFM genome. Globally, 111 single nucleotide polymorphisms (SNPs) (95 SNPs, 16 indels) were observed throughout the genome. Also, a 416-bp deletion in the LA14_1146 sugar ABC transporter was identified.