Asthma is a complex disease, often with evident genetic predisposition; for example, the single‑nucleotide polymorphism (SNP) rs7130588 was significantly associated asthma by genome‑wide association study (GWAS). Analysis of 1000 Genomes Project data suggests that there another SNP, rs6592645, in complete linkage disequilibrium and should present same signal GWAS. However, causal SNP mechanism ...

SUMMARY We have created a software tool, SNPTools, for analysis and visualization of microarray data, mainly SNP array data. The software can analyse and find differences in intensity levels between groups of arrays and identify segments of SNPs (genes, clones), where the intensity levels differ significantly between the groups. In addition, SNPTools can show jointly loss-of-heterozygosity (LOH...

A single nucleotide polymorphism (SNP) in CD24 has been associated with multiple sclerosis (MS) in a population based study. This SNP results in the replacement of alanine (CD24A) by valine (CD24V) at amino acid 57 in the resulting polypeptide chain. In the current study, the genotyping of this SNP and its contribution to MS in 217 patients and 200 healthy individuals of an Iranian population w...

Background: Type 1 diabetes mellitus (T1DM) is a chronic, immune-mediated disease characterized by the destruction of insulin-producing β cells in pancreas. This study investigated influence single nucleotide polymorphisms (SNP) tumor necrosis factor (TNF-α) –308 G/A (rs1800629,) on T1DM patients. Method: The was included 75 patients and 25 healthy subjects. SNP–308 TNF-α gene detected using po...

OBJECTIVE We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples. METHODS Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls. RESULTS TLR9 1635A/G was associated with reduced HIV-1 acquisition am...

Highly accurate and reliable genotype calling is an essential component of any highthroughput SNP genotyping technology. BRLMM, the method of choice for the Mapping 500K product, is effective, but requires the presence of mismatched probes (MM) probes on the array to create “seed” genotypes. We present here a method that only uses perfect-match probes, BRLMM-P. The primary difference between BR...

Hynobius amjiensis was considered as one of the 29 most threatened amphibian in China. To effectively conserve, manage and recover population this critically endangered species, 33 single nucleotide polymorphism (SNP) markers were developed using double digest restriction-site associated DNA (ddRAD) sequencing. The minor allele frequency per locus ranged from 0.0161 to 0.5000. observed heterozy...

Title of Document: BAYESIAN ESTIMATION OF THE INBREEDING COEFFICIENT FOR SINGLE NUCLEOTIDE POLYMORPHISM USING COMPLEX SURVEY DATA Zhenyi Xue, Doctor of Philosophy, 2015 Directed By: Professor Partha Lahiri Associate Professor Yan Li Joint Program in Survey Methodology In genome-wide association studies (GWAS), single nucleotide polymorphism (SNP) is often used as a genetic marker to study gene-...

Abstract The mountain lion ( Puma concolor ) is one of the few remaining large predators in California, USA with density estimation from fecal genotypes becoming an essential component conservation and management. In highly urbanized southern lions are fragmented into small, inbred populations making proper marker selection critical for individual identification. We developed a panel single nuc...

Leptin (LEP), the expression product of the obese gene produced primarily in the adipose tissue, is related to feed intake, growth and lipid metabolism. The aim of this study was to study the possible association between polymorphism of the LEP gene with growth and carcass traits among three Iranian sheep breeds of the Shal, Zandi and Zel varieties. A total of 180 purebred animals of the Shal, ...