Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signa...

Techniques are reviewed and presented for alias-free digital synthesis of classical analog synthesizer waveforms such as pulse train and sawtooth waves. Techniques described include summation of bandlimited primitive waveforms as well as table-lookup techniques. Bandlimited pulse and triangle waveforms are obtained by integrating the difference of two out-of-phase bandlimited impulse trains. Ba...

We provide sufficient conditions for vector-valued Fredholm integral operators and their commonly used spatial discretizations to be positive in terms of an order relation induced by a corresponding cone. It turns out that reasonable Nyström methods preserve positivity. Among the projection methods, persistence is obtained simplest ones based on polynomial, piecewise linear or specific cubic in...

PURPOSE To develop a fast and stable method for correcting the gibbs-ringing artifact. METHODS Gibbs-ringing is a well-known artifact which manifests itself as spurious oscillations in the vicinity of sharp image gradients at tissue boundaries. The origin can be seen in the truncation of k-space during MRI data-acquisition. Correction techniques like Gegenbauer reconstruction or extrapolation...

We evaluate the performance and statistical accuracy of the fast Fourier transform method for unconditional and conditional simulation. The method is applied under difficult but realistic circumstances of a large field (1001 by 1001 points) with abundant conditioning criteria and a band limited, anisotropic, fractal-based statistical characterization (the von Kármán model). The simple Fourier u...

We investigate the use of direct-Fourier (DF) image reconstruction in computerized tomog-raphy and synthetic aperture radar (SAR). One of our aims is to determine why the convolution-backprojection (CBP) method is favored over DF methods in tomography, while DF methods are virtually always used in SAR. We show that the CBP algorithm is equivalent to DF reconstruction using a Jacobian-weighted 2...

The maintenance of nuclear compartmentalization by the nuclear envelope and nuclear pore complexes (NPCs) is essential for cell function; loss of compartmentalization is associated with cancers, laminopathies, and aging. We uncovered a pathway that surveils NPC assembly intermediates to promote the formation of functional NPCs. Surveillance is mediated by Heh2, a member of the LEM (Lap2-emerin-...

OFDM is a form of multicarrier modulation technique with high spectral efficiency, robustness to channel fading, immunity to impulse interference, uniform average spectral density capacity of handling very strong echoes and non-linear distortion. Despite of its many advantages, one major disadvantage of OFDM is that the time domain OFDM signal which is a sum of several sinusoids leads to high p...