Although IP Multicast offers efficient data delivery for large group communications, the most critical issue delaying widespread deployment of IP Multicast is the scalability of multicast forwarding state as the number of multicast groups increases. Sender-Initiated Multicast (SIM) was proposed as an alternative multicast forwarding scheme for small group communications with incremental deploym...

The USP1/UAF1 complex deubiquitinates the Fanconi anemia protein FANCD2, thereby promoting homologous recombination and DNA cross-link repair. How USP1/UAF1 is targeted to the FANCD2/FANCI heterodimer has remained unknown. Here we show that UAF1 contains a tandem repeat of SUMO-like domains in its C terminus (SLD1 and SLD2). SLD2 binds directly to a SUMO-like domain-interacting motif (SIM) on F...

In this paper, a simulation model for IEEE 802.16 (WiMAX) wireless mesh networks with distributed scheduling is developed. It provides a framework for the evaluation of reservation-based distributed scheduling (RBDS) policies at the medium access control (MAC) layer. The simulation model, called WiMAX-RBDS-Sim, is developed under the OPNET event-driven simulation environment. It provides interf...

In this paper a hybrid modulation scheme based on pulse position modulation (PPM) and binary phase shift keying subcarrier intensity modulation (BPSK-SIM) schemes for free-space optical communications is proposed. The analytical bit error rate (BER) performance is investigated in weak and saturated turbulence channels and results are verified with the simulation data. Results show that performa...

in this paper, some results of singh, gopalakrishna and kulkarni (1970s) have been extended to higher order derivatives. it has been shown that, if $sumlimits_{a}theta(a, f)=2$ holds for a meromorphic function $f(z)$ of finite order, then for any positive integer $k,$ $t(r, f)sim t(r, f^{(k)}), rrightarrowinfty$ if $theta(infty, f)=1$ and $t(r, f)sim (k+1)t(r, f^{(k)}), rrightarrowinfty$ if $th...

Background Barrett esophagus is an acquired, premalignant condition caused by chronic gastroesophageal refllux, in which the normal squamous epithelium in the distal esophagus is replaced by columnar epithelium. Barrett’s esophagus is considered to follow a multistep process progression from intestinal metaplasia to low-grade dysplasia (LGD) to high-grade dysplasia (HGD) and finally to esophage...

PURPOSE c-Met and its ligand, hepatocyte growth factor (HGF), play a critical role in oncogenesis and metastatic progression. The aim of this study was to identify inhibited enzymogram and to test the antitumor activity of SIM-89 (a c-Met receptor tyrosine kinase inhibitor) in non-small cell lung cancer. MATERIALS AND METHODS Z'-LYTE kinase assay was employed to screen the kinase enzymogram, ...

ID: 4741 Title: On the Dose Delivered to a Moving Target When Employing Different IMRT Delivery Mechanisms Purpose: To investigate the influence of target motion on dose distributions generated using unmodulated open fields, solid intensity modulator (SIM), Step and Shoot MLC (SMLC) and dynamic MLC (DMLC). Method and Materials: For two lung cancer cases, four treatment plans were generated usin...