Asphyxia due to extrinsic tracheal compression by nonresectable tumour in the mediastinum is a particularly distressing problem, hitherto not amenable to relief by surgical means. Tracheostomy may be inappropriate, either because the tube falls short of the area of compression or because the segment of trachea at the tracheostomy site is affected by the pathological process; and endotracheal in...

Middle meatal adhesions are considered the most common complication of Functional Endoscopic Sinus Surgery (FESS), ranging in incidence from 1 to 36%. Consequently the recurrence and persistence of symptoms increase, resulting in revision surgery in up to 25% of the cases. Although different methods have been attempted to prevent adhesions, each procedure involves some disadvantages and no stan...

The transport of sterols incorporated into the lecithin bilayer of small unilamellar liposomes through a model membrane was studied. A two-chamber diffusion cell containing liposomes with incorporated [4-14C)cholesterol or beta-[4-14C]sitosterol in the donor chamber and liposomes with unlabeled cholesterol in the receiver chamber was used. The permeability coefficients of the sterols through si...

Viewed in retrospect, the development of hormonal methods of fertility control could be broadly divided into three main phases: (i) development of the oral contraceptive 'Pill based on synthetic ovarian steroid hormones; (ii) the demonstration that continuous oral administration of progestins in microdoses could effectively prevent an undesired pregnancy[1]; and (iii) the development of sustain...

We developed a heterologous system to study the effect of mechanical deformation on alveolar epithelial cells. First, isolated primary rat alveolar type II (ATII) cells were plated onto silastic substrata coated with fibronectin and maintained in culture under conditions where they become alveolar type I-like (ATI) cells. This was followed by a second set of ATII cells labeled with the nontrans...

Our previous studies demonstrated that the sexually dimorphic pattern of hypertension in the spontaneously hypertensive rat is androgen dependent. Gonadectomy retards the development of hypertension in young males, but not in females, and administration of testosterone propionate to gonadectomized spontaneously hypertensive rats of both sexes confers a male pattern of blood pressure development...

There are sex differences in the symptomatology of schizophrenia, and in the response to antipsychotic treatments. One hallmark symptom of schizophrenia is a deficit in selective attention. Selective attention can be measured using a latent inhibition (LI) paradigm in humans; LI can be measured in rodents, and is used as an animal model of the selective attention deficits observed in schizophre...

BACKGROUND We evaluated the influence of chemical disinfection and accelerated aging on the dimensional stability and detail reproduction of a silicone elastomer containing one of two opacifiers. METHODS A total of 90 samples were fabricated from Silastic MDX 4-4210 silicone and divided into groups (n = 10) according to opacifier content (barium sulfate or titanium dioxide) and disinfectant s...