Community interest in blindness was limited to simple charity for those afflicted until ophthalmology became a true science. Not until 1851 did Helmholtz develop the ophthalmoscope, and the first Professorship of Ophthalmology in the United States was not established until 1860 at Miami University. The first lecturer in ophthalmology at Yale, Dr. William Carmalt, was appointed in 1876. Since th...

TIN filaments are required for cell locomotion and numerous intracellular activities in nonmuscle cells, and are a major component of the contractile apparatus in muscle cells. An understanding of the dynamics involved in the assembly and disassembly of actin filaments is fundamental to understanding many cellular functions. In this issue of The Journal of Cell Biology, Weber et al. (1994b) pro...