In this double-blind, randomized, placebo-controlled study, we investigated the effect of an infant milk formula with 6 g/L short-chain galacto- and long-chain fructo-oligosaccharides [(scGOS/lcFOS) ratio 9:1] on the development of the fecal secretory immunoglobulin A (sIgA) response and on the composition of the intestinal microbiota in 215 healthy infants during the first 26 wk of life. The i...

OBJECTIVE To evaluate the hypothesis that breast-feeding women who participate in relaxation training will have increased secretory IgA (sIgA) levels in their breast milk compared with women not receiving training. DESIGN Nonrandomized control trial of a convenience sample. SETTING Women were recruited from the postpartum floor of a university teaching hospital. The intervention took place ...

Purpose: The aim of the study was to evaluate the mucosal immune function and circadian variation of salivary cortisol, Immunoglobin-A (sIgA) secretion rate and mood during a period of high-intensity interval training (HIIT) compared to long-slow distance training (LSD). Methods: Recreational male runners (n = 28) completed nine sessions of either HIIT or LSD within 3 weeks. The HIIT involved 4...

Background: Early Childhood Caries (ECC) is one of the most common chronic child-hood diseases. In spite of the global decrease in dental caries in the past decades, ECC has become a significant problem in many developing countries and also in a few indus-trialized nations. Saliva as a host factor can play an important role in the process of den-tal caries. Objective: The aim of this study was ...

Our previous studies indicated that cloned T cells obtained from Peyer's patches (PP) (Lyt-1+, 2-, Ia+, and H-2K/D+) evoked immunoglobulin (Ig) class switching of PP B cells from sIgM to sIgA cells in vitro; however, these switch T cells could not in themselves provide optimal help for the differentiation of postswitch sIgA-bearing PP B cells to IgA-secreting cells. Thus, in the present report ...

Background Secretory IgA (sIgA) content of breastmilk in the first postpartum month is a reflection pregnant woman's immune response to environmental antigen exposure. The role secretory protect and support development neonatal early life.
 Objective To examine possible factors associated with sIgA levels colostrum, including exposure, food consumed, maternal history atopy, appearance alle...

The nasal cavity is a primary checkpoint for the invasion of respiratory pathogens. Numerous pathogens, including SARS-CoV-2, S. pneumoniae, aureus, etc., can adhere/colonize lining to trigger an infection. Secretory IgA (sIgA) serves as first line immune defense against foreign sIgA facilitates clearance pathogenic microbes by intercepting their access epithelial receptors and mucus entrapment...

Error performance of DS-CDMA is discussed over independent Rayleigh faded multipath channel employing selective Rake (SRake) receiver. Simple-to-evaluate and accurate error probabilities are given following Holtzman’s simplified improved Gaussian approximation (SIGA). Comparing with SIGA, the validity of standard Gaussian approximation (SGA) is then verified. It is shown that SGA is accurate fo...

In this Research Topic of Frontiers in Mucosal Immunology we have focused on gut IgA B cell responses. We have invited world leading researchers in the field to contribute with articles that give the most recent up-date on our current understanding of this interesting and complex protective system. Because a majority of all human pathogens access the body via the mucosal membranes we need an ef...