OBJECTIVE The aim of this exploratory, cross-sectional study was to evaluate pain in sickle cell disease patients and aspects related to primary healthcare. METHODS Data were obtained through home interviews. The assessment instruments (body diagram, Numerical Pain Scale, McGill Pain Questionnaire) collected information on the underlying disease and on pain. Data were analyzed using the Stati...

Abstract Introduction Sickle cell disease (SCD) is a genetic hemoglobinopathy with clinical and epidemiological relevance. Its manifestations directly affect the quality of life affected individuals. There gap in literature regarding approach to aspects related sexual reproductive health people sickle disease, especially female population, given that most available studies evaluated men. The ai...

background: molecular genetic factors regulating hemoglobin f (hb f) expression are important modifiers of the severity of sickle cell anemia (ss).   methods: the prevalence of xmni polymorphic site, the g g: a g ratio and the hb f level were determined using pcr-rflp procedure, hplc and alkaline denaturation method, respectively, in various haplotypes of 52 patients with ss, 18 patients with s...

Sickle cell disease affects more than 100,000 individuals in the United States, among whom disease severity varies considerably. One factor that influences disease severity is the sickle cell disease genotype. For this reason, clinical prevention and treatment guidelines tend to differentiate between genotypes. However, previous research suggests caution when using a claimsbased determination o...

OBJECTIVE Sickle cell disease is a hereditary disease, which affects mainly the black population. The aim of the present study was to analyze hospital admissions due to acute events resulting from sickle cell disease, at the epidemiological and clinical levels. METHODS The study population included 9,349 patients with sickle cell disease admitted to hospitals in Bahia, Rio de Janeiro, and Sao...