Alteration in length of the distal ulna may provide an attractive alternative to more destructive procedures commonly used for the treatment of mechanical and degenerative problems at the distal radioulnar joint. Ulnar recession has shown effectiveness in ulnolunate impingement, triangular fibrocartilage tears, and symptomatic ulnar plus variance. It has also been effective in chondromalacia of...

We attempted to clarify myocardial telomere dynamics using samples from 530 autopsied patients using Southern blot analysis. Overall regression analysis demonstrated yearly telomere reduction rate of 20 base pairs in the myocardium. There was a significant correlation between myocardial telomere and aging. Moreover, regression analyses of telomere and heart weight yielded a telomere reduction r...

Telomere maintenance is critical in tumor cell immortalization. Here, we report that the cytokine bone morphogenetic protein-7 (BMP7) inhibits telomerase activity that is required for telomere maintenance in cervical cancer cells. Application of human recombinant BMP7 triggers a repression of the human telomerase reverse transcriptase (hTERT) gene, shortening of telomeres, and hTERT repression-...

Telomerase is a ribonucleoprotein that maintains the ends of linear chromosomes in most eukaryotes. Loss of telomerase activity results in shortening of telomeric DNA and eventually a specific G2/M cell-cycle arrest known as senescence. In humans, telomere shortening occurs during aging, while inappropriate activation of telomerase is associated with approximately 90% of cancers. Previous studi...

Introduction Former experiments have shown an increased number of non-transmissible chromosomal aberrations in the progeny of normal human fibroblasts after irradiation with Xrays [1, 2]. These de novo formed non-transmissible aberrations are an indicator of genomic instability which is considered to be one important step towards carcinogenesis. In parallel experiments we observed accelerated s...

Telomere shortening is the mechanism underlying replicative aging in fibroblasts. A variety of reports now claim that inactivation of the p16(INK4a)/pRB pathway is required in addition to telomere maintenance for the immortalization of cells such as skin keratinocytes and breast epithelial cells. We here show that the premature growth arrest of these cell types can be explained by an inadequate...

Production of a new mechanism involves design, manufacturing and testing phases. In order to achieve shorter turn-around times, researchers have studied methods of shortening these phases. Today, structural tests and simulations conducted in virtual environments prior to manufacturing are a part of most of the standard production processes. However, in robot production not only the structural a...

Some subduction zones in nature show mainly overriding plate (OP) extension and low topography, others shortening elevated topography. Here we investigate how end-member modes (trench retreat with slab rollback trench advance rollover) affect deformation (OPD), topography mantle flow time-evolving three-dimensional fully-dynamic analog models using particle image velocimetry (PIV). We conduct t...

Recent reports express concern about the sustainability of biomedical research enterprise in its current form. Recurring concerns include predictability and funding for research, regulatory burden training next generation workforce. One specific is duration periods during pre-doctoral post-doctoral studies. This article addresses issue time-to-degree (TTD) doctorates. Many stress importance sho...