Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeo...

Shivering is the only universal facultative thermogenic mechanism in endothermic vertebrates. Skeletal muscle constitutes a large proportion of body mass and a high scope of metabolic rate, and thus heat production, between resting level and active contraction. Its contractile activity is under rapid and accurate neural control. Together with the inherently low metabolic efficiency of muscle, t...

Mammals and birds are endotherms and respond to cold exposure by the means of regulatory thermogenesis, either shivering or non-shivering. In this latter case, waste of cell energy as heat can be achieved by uncoupling of mitochondrial respiration. Uncoupling proteins, which belong to the mitochondrial carrier family, are able to transport protons and thus may assume a thermogenic function. The...

KMEN, AaaoT-r T., CLIFFORD B. REIFLER, AND VIcroR H. shivering. The predominant role oi the peripheral mecha"THALV2. Modification of thermoregulatory response to cold by hypnosis. nism in the initiation of shivering has been stressed by J. Appl. Physiol. i9(6): 1o43-1050. i9 64 .-The effects of Lim (27). Helmendach and Meehan (16) noted that the hypnosis on thermoregulatory responses were studi...

Background of this study: Shivering is the most general adverse effect occurs after administration anaesthesia with several aetiologies. In order to control shivering, drug such as tramadol broadly required. Nausea well vomiting majorly caused by tramadol. Therefore, there a search for efficient that lacking effects. Aim The goal study was evaluate efficiency dexmedetomidine in medication post ...

OBJECTIVE The aim of this study was to investigate the optimum dosage of dexmedetomidine for prevention of postanesthetic shivering. METHODS One-hundred thirty two ASA physical status I-II patients scheduled for elective laparoscopic total hysterectomy were enrolled in this randomised, placebo-controlled study. Patients were randomly allocated to receive dexmedetomidine in four groups: group ...

BACKGROUND JM-1232(-) is a novel isoindoline derivative which shows sedative and hypnotic activities through the benzodiazepine site of gamma-aminobutyric acid type A (GABAA) receptors. Typical doses of midazolam, another GABAA receptor agonist, slightly reduce the shivering threshold in humans. We thus determined the extent to which JM-1232(-) decreases the shivering threshold. METHODS Eight...

Brown adipose tissue (BAT) activity is induced when humans are exposed to cold. Therefore, cold exposure prior to the 18F-FDG-PET/CT scan is used as a tool to quantify BAT. Several cooling protocols, including fixed and personalized ones are currently in use. The aim of the present study was to determine the effect of a new personalized cooling protocol where the shivering threshold was measure...

Spinal anesthesia significantly results in shivering and hypothermia as unwanted effect. Shivering increases oxygen consumption which may be deleterious patients who have low cardiac pulmonary reserve. We conducted this study to evaluate the efficacy of Ketamine Granisetron for prevention under spinal anesthesia. In randomized prospective study, 90 Patients aged 18-60 years ASA physical status ...