The SH2-containing inositol-5'-phosphatase, SHIP, represses the proliferation, survival, and activation of hematopoietic cells, in large part by translocating to membranes following extracellular stimulation and hydrolysing the phosphatidylinositol-3-kinase (PI3K)-generated second messenger PI-3,4,5-P3 (PIP3) to PI-3,4-P2. SHIP-/- mice have, as a result, an increased number of monocyte/macropha...

Protein kinase C(PKC) is expressed in platelets and activated downstream of protease-activated receptors (PARs) and glycoprotein VI (GPVI) receptors. We have previously shown that PKCpositively regulates PAR-mediated dense granule secretion, whereas it negatively regulates GPVI-mediated dense granule secretion. We further investigated the mechanism of such differential regulation of dense granu...

In this study, we propose a Support Vector Machine (SVM) based method for ship detection in polarimetric SAR (POLSAR). Because of similarities of ship and man-made structures on land in scattering mechanisms, land and sea are first segmented by SVM according to polarimetric features and texture features; The SVM-based Recursive Feature Elimination (RFE-SVM) approach is adopted to improve the pe...

The SH2 domain-containing inositol 5'-phosphatase (SHIP) plays a key role in preventing autoimmune phenomena by limiting antigen-mediated B cell activation. SHIP function is thought to require the dual engagement of the BCR and negative regulatory coreceptors as only the latter appear capable of recruiting SHIP from the cytosol to the plasma membrane by the virtue of phosphorylated immunorecept...

Moonpool is an opening in the floor or base of a hull ship which can be used to lower tools and vehicles into the sea in a protected area. In this paper, the effect of a rectangular cross section moonpool on the resistance force of a supply vessel was investigated both by experimental and numerical methods. For both methods a 1:37.2 scale of Caspian3 surface vessel was used. Experiments were ca...

Is fundamental change possible in the tradition-bound world of college and university science education? The Howard Hughes Medical Institute (HHMI) believes it is and recently announced new grants to empower individual scientisteducators—the HHMI Professors—to develop innovative approaches for changing the way they teach biology to undergraduates. Central to the Professors program is the goal o...

BACKGROUND The attention placed on cruise ship infectious epidemics has helped create important preventive strategies in improving food handling, sanitation, and overall cruise ship medical care. However, the incidence of serious injury in cruise ship passengers has never been fully described. In 2006, there was an increase in the number of cruise ship passengers receiving medical care at a Lev...

This paper presents a new simulation model for long-term optimization of channel depths in which the risk of ship grounding due to wave impacts can be considered for every ship transit. This new model includes four main components: (1) an exponential probability law for a number of ship departures; (2) a parametric model of the wave-induced ship motions; (3) modeling effects of tidal variations...

The activation of Fli-1, an Ets transcription factor, is the critical genetic event in Friend murine leukemia virus (F-MuLV)-induced erythroleukemia. Fli-1 overexpression leads to erythropoietin-dependent erythroblast proliferation, enhanced survival, and inhibition of terminal differentiation, through activation of the Ras pathway. However, the mechanism by which Fli-1 activates this signal tr...

Underwater radiated noise measurements for seven types of modern commercial ships during normal operating conditions are presented. Calibrated acoustic data (<1000 Hz) from an autonomous seafloor-mounted acoustic recorder were combined with ship passage information from the Automatic Identification System. This approach allowed for detailed measurements (i.e., source level, sound exposure level...