BACKGROUND Dendritic cells (DCs) not only play a crucial role in activating immune cells but also suppressing them. We recently investigated SHIP's role in murine DCs in terms of immune cell activation and found that TLR agonist-stimulated SHIP-/- GM-CSF-derived DCs (GM-DCs) were far less capable than wild type (WT, SHIP+/+) GM-DCs at activating T cell proliferation. This was most likely becaus...

Ship detection is an inherent process supporting tasks such as fishery management, ship search, marine traffic monitoring and control, and helps in the prevention of illegal activities. So far, sea and shore monitoring has been carried out by ship patrols and aircrafts along with sea vessel detection from data from space-borne platforms. Recently an increase interest in applying images delivere...

Air-sea exchange of CO2 is parameterized along the cruise track of Galathea 3 – a worldwide research expedition. A key parameter is the gas transfer velocity, which varies with wind speed. Wind speeds are measured continuously on board the research vessel. For selected areas, winds are also retrieved from Envisat ASAR images, as the ASAR senses small-scale waves at the sea surface generated by ...

Ship is a recently identified SH2-containing inositol polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems. To understand the physiologic function of Ship in vivo, we performed expression studies of Ship during mouse development. Results of this study demonstrate the expression of ship to be in late primitive-streak stage embryos (7.5 d...

The BCR/ABL oncogene causes chronic myelogenous leukemia (CML), a myeloproliferative disorder characterized by clonal expansion of hematopoietic progenitor cells and granulocyte lineage cells. The SH2-containing inositol-5-phosphatase SHIP is a 145-kDa protein which has been shown to regulate hematopoiesis in mice. Targeted disruption of the murine SHIP gene results in a myeloproliferative synd...

SHIP-1 negatively regulates the PI3K pathway in hematopoietic cells and has an emerging role in T lymphocyte biology. PI3K and SHIP can regulate cell migration in leukocytes, particularly in neutrophils, although their role in T cell migration has been less clear. Therefore, we sought to explore the role of SHIP-1 in human CD4(+) T lymphocyte cell migration responses to chemoattractants using a...

This work investigates a new error source for angular velocity or attitude-based transfer alignment, which is caused by the coupling influence of dynamic flexure with ship angular motion. Most traditional studies do not consider this coupling error, as they often assume that dynamic flexure and ship angular motion are uncorrelated. However, the correlation between the dynamic flexure and the sh...

Mandatory or voluntary reductions in ship speed are a common management strategy for reducing deleterious encounters between large ships and large whales. This has produced strong resistance from shipping and marine transportation entities, in part because very few studies have empirically demonstrated whether or to what degree ship speed influences ship-whale encounters. Here we present the re...

Mitochondria in the protist Brevimastigomonas motovehiculus are in the process of dismantling their mitochondrial electron transport chain complexes as they adapt to anaerobic environments. Novel protein interactions suggest a highly complicated process rather than the simple removal of unnecessary genes.