Calcific aortic stenosis is the most common aortic valve (AV) disease and is triggered by an active inflammatory process involving endothelial activation and cytokine expression. Interfacing between the leaflet and the surrounding blood flow, shear stress is presumed to play an important role in endothelial injury. This study investigated the hypothesis that pathologic alterations in shear stre...

Two novel mathematical models based on polynomial function (PF) and boundary condition method (BCM) are presented for determination of shear stress in interface in steady state creep in short fiber composites under axial loading. Important novelty of this research is determination of shear stress in interface without using of shear lag and imaginary fiber technique (IFT) theories. In these appr...

Atherosclerosis, the leading cause of death in the developed world and nearly the leading cause in the developing world, is associated with systemic risk factors including hypertension, smoking, hyperlipidemia, and diabetes mellitus, among others. Nonetheless, atherosclerosis remains a geometrically focal disease, preferentially affecting the outer edges of vessel bifurcations. In these predisp...

This study directly measured the relative protein levels in bovine aortic endothelial cells (BAEC) that were cultured for two weeks in normal (5 mM, NG) or high (22 mM, HG) glucose and then were subjected to laminar shear stress at 0 or 15 dynes/cm(2). Membrane preparations were labeled with one of the four isobaric tagging reagents (iTRAQ), followed by LC-MS/MS analysis. The results showed tha...

Dynamic response of microemulsions to shear deformation on the basis of twoorder-parameter time dependent Ginzburg-Landau model is investigated by means of cell dynamical system approach. Time evolution of anisotropic factor and excess shear stress under steady shear flow is studied by changing shear rate and total amount of surfactant. As the surfactant concentration is increased, overshoot pe...

The radiation of elastic waves from a localized source is observed experimentally in a two-dimensional plasma crystal. An initial shear stress applied by a laser forms a small dipole source. The emerging complex wave pattern is shown to consist of outgoing compressional and shear wave pulses. Subsequent structures are identified as inward-going waves due to the finite size of the source region,...

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Shear deformations of Cu57Zr43 bulk metallic glass (BMG) model systems are performed using molecular dynamics simulation. The results suggest that both the hydrostatic stress and the stress normal to the shear plane should affect the shear response (modified Mohr–Coulomb yield criterion). We see shear localization and shear band nucleation in both a small system of 2000 atoms, and large systems...

The purpose of this study was to understand bacteria profile modification and its applications in subsurface biological operations such as biobarrier formation, in situ bioremediation, and microbial-enhanced oil recovery. Biomass accumulation and evolution in porous media were investigated both experimentally and theoretically. To study both nutrient-rich and carbon-source-depleted conditions, ...

A major consequence of stent implantation is restenosis that occurs due to neointimal formation. This patho-physiologic process of tissue growth may not be completely eliminated. Recent evidence suggests that there are several factors such as geometry and size of vessel, and stent design that alter hemodynamic parameters, including local wall shear stress distributions, all of which influence t...