BACKGROUND Preeclampsia is a leading cause of maternal and perinatal mortality worldwide. The exact etiology of preeclampsia is unknown, but the inflammatory process is postulated as one of the etiologies. Red blood cell distribution width (RDW) is a measure of anisocytosis (variation of red cell size) and is associated with hypertension and diabetic ketoacidosis. There are few data on the asso...

The aim of this study was to investigate the maternal serum of soluble human leukocyte antigen G (sHLA-G) levels in pregnancies complicated by severe preeclampsia. Patients and methods: The study was conducted on 43 patients with pregnancy complicated by severe preeclampsia (the PRE group). The control group consisted of 30 healthy normotensive patients with singleton uncomplicated pregnancies ...

OBJECTIVE To estimate the possibility of long-term effects of subclinical thyroid dysfunction on hypertension and other cardiovascular-related conditions during pregnancy. METHODS This is a secondary analysis of a prospective prenatal population-based study in which serum thyroid-function analytes were measured from November 2000 through April 2003. Women with evidence of overt thyroid diseas...

BACKGROUND Preeclampsia and coronary-artery disease share risk factors, suggesting common pathophysiological mechanisms. CX3CR1/CX3CL1 mediates leukocyte migration and adhesion and has been implicated in the pathophysiology of several inflammatory diseases. M280/I249 variants of CX3CR1 are associated with an atheroprotective effect and reduced endothelial dysfunction. The aim of this study was ...

We previously hypothesized that the endothelial cell dysfunction observed in women with preeclampsia might be caused by an imbalance between circulating very low density lipoproteins and a cytoprotective pI 5.6 isoform of albumin, referred to as toxicity preventing albumin (TxPA). An accurate simplified method was developed to quantify TxPA in small volumes of pregnancy plasma by gel electrofoc...

Preeclampsia and eclampsia are types of gestational hypertension that considered causes maternal perinatal death. in severe conditions will result accompanied by symptoms seizures or decreased consciousness. In the condition preeclampsia, antihypertensive therapy is needed. The use antihypertensives patients with Eclampsia, namely methyldopa labetalol, first line, hydralazine, nifedipine, prazo...

Background: Preeclampsia is an obstetric disorder affecting 2-8% pregnancies globally and 8-10% in India. The study was conducted to evaluate platelet count, mean volume distribution width as potential predictor of preeclampsia. It also aimed see if these indices have a prognostic significance determining the preeclampsia severity.Methods: A prospective on 120 pregnant women at 20 24 weeks gest...

This report defines the nature of the molecules responsible for the increased plasma plasminogen activator inhibitor (PAI) activity in preeclamptic patients and the relationship of these inhibitors to the severity of placental damage in preeclampsia. Clinical groups consisting of pregnant women with either severe preeclampsia or chronic hypertension with superimposed severe preeclampsia, as wel...