background nephrotoxicity and hepatotoxicity are side effects of cisplatin (cp) therapy. objectives we investigated the role of gender in cp-induced nephrotoxicity and hepatotoxicity. materials and methods low dose of cp (1 mg/kg/day; ip) was administered daily to male and female wistar rats for 15 consecutive days. serum creatinine (cr), blood urea nitrogen (bun), malondialdehyde (mda), nitric...

Serum PD-L1 (sPD-L1) levels are associated with prognosis in various tumors but has not yet been investigated advanced bladder cancer. We assessed pretreatment serum samples from 83 BC patients who received platinum chemotherapy and 12 underwent immune checkpoint inhibitor (ICI) therapy. In addition, on-treatment further therapy cycles were collected during (n = 58) ICI 11). determined using EL...

Serum therapy in the form in which it finds application in the treatment of diphtheria patients is an antitoxic or detoxicating curative method. It is based on the view, held by Löffler in Germany and by Roux in France, that the parasites causing diphtheria, the Löffler diphtheria bacilli, do not themselves cause diphtheria, but that they produce poisons which cause the disease to develop. With...

OBJECTIVE The purpose of this study was to compare the incidence of nephrotoxicity, defined as doubling of baseline serum creatinine concentration, in newborn infants with peak vancomycin serum concentrations 40 microg/mL. A secondary objective was to correlate concomitant disease states and potentially nephro...

_ By D. N. SEN, l-m.s., Pathologist, Sambhunath Pandit Hospital, Alipore? Note by Major GOURLAY, d-s.o-, Surgeon Supdt., Sambhunath Pandit Hospital. In introducing this paper by Dr. D. N. Sen, Pathologist of the Sambhunath Pandit Hospital. I must admit that I have no first-hand acquaintance with the literature of auto-haemic therapy. At the same time, the subject appears to be an extraordinaril...

Several drugs used for standard antihypertensive therapy may also interact with the lipoprotein metabolism. The following has been observed after 1 to 12 months of treatment. Various thiazide-type diuretics may significantly increase the potentially atherogenic serum low-density-lipoprotein cholesterol (LDL-C) and/or very-LDL-C-fractions, while the antiatherogenic high-density-lipoprotein chole...

To perform PCR from serum for the diagnosis of visceral leishmaniasis is convenient and much less invasive than examination deeper compartments such as bone marrow. We compared three Leishmania-specific real-time PCRs with different molecular targets (kinetoplast DNA, small subunit-ribosomal RNA-(ssrRNA-)gene, glucose-6-phosphate isomerase-(gpi-)gene) regarding their sensitivity specificity in ...