leptin, a circulating 16-kd polypeptide consisting of 167 amino acids, appears to be involved in the body weight homeostasis. moreover leptin plays an important role for the reproductive system, early embryogenesis, and fat metabolism during pregnancy and puberty. significant correlations have been found between leptin and sexual hormones, which is a cytokine and has hormonal properties. the ai...

Background: With the growing population of the elderly, the prevalence of disabilities and chronic diseases will also likely increase. Muscle weakness leads to low amounts of physical activity in elderly diabetic patients and makes them susceptible to falls. In this study, we aimed to compare the muscle strength between diabetic and non-diabetic elderly individuals. Methods: The present study ...

objective: serum leptin concentration reflects the body fat mass. there is controversial reports about the insulin effect on serum leptin concentration. we wanted to examine the effect of insulin therapy on serum leptin in children with new onset type i diabetes. materials and methods: this was a cross-sectional study in children's medical center on 34 children who had new onset type i dia...

Introduction:Obesity is one of the most serious challenges of our era, with significant health consequences and high economic burden for health systems. Therefore, many countries have developed political agendas to cope with this ever-rising challenge. Along with chemical medications that are developed to manage obesity, researchers have focused on some natural ingredients and herbal extracts w...

background and objectives: sarcopenia is explained as age-related reduction in muscle mass and performance. some of the most important risk factors for sarcopenia include age, malnutrition, and sedentary life style. the aim of this study was to investigate the association of food intake and physical activity with body composition, muscle strength and muscle function in post-menopausal women. ma...

objectives: the relation of metabolic syndrome components, insulin resistance and leptin has been studied in elderly women. methods & materials: in this cross sectional study, among 225 subjects≥60 year old who were residents of kahrizak charity foundation, 133 (56 men & 77 women) were selected by cluster random sampling. fasting serum tg, total cholesterol, hdl, and leptin levels were measured...

Background and Objectives: Calorie restriction (CR) is one of the proven methods of extending lifespan and slowing aging. Leptin is a nutritionally regulated adipokine that has been proposed as a possible key signal in the adaptive responses relevant to CR. Under CR, plasma leptin levels decrease, thus it was hypothesized that leptin administration may counteract CR-induced weight loss. Therefo...