نتایج جستجو برای: serum leptin

تعداد نتایج: 319768  

Journal: :European journal of endocrinology 2001
M Schroth M Gröschl H G Dörr W F Blum W Rascher J Dötsch

OBJECTIVE In humans, short term changes of serum leptin lead to alterations in food intake and energy expenditure. The objective of the present study was to relate urine leptin concentrations with the extent of proteinuria in patients with nephrotic syndrome (NS). A second goal was to investigate the impact of potential urinary leptin losses on serum leptin concentrations and body composition. ...

2017
Pei-Wei Tseng Du-An Wu Jia-Sian Hou Bang-Gee Hsu

OBJECTIVE It is well established that patients with metabolic syndrome (MetS) demonstrate elevated levels of serum leptin. The aim of this study is to identify fasting serum leptin as an independent marker of MetS in geriatric diabetic patients. MATERIALS AND METHODS Sixty-four patients over 65 years old with type 2 diabetic mellitus (T2DM) were assessed for MetS based on the diagnostic crite...

Journal: :The Journal of endocrinology 2008
Gideon Hen Sera Yosefi Ana Ronin Paz Einat Charles I Rosenblum Robert J Denver Miriam Friedman-Einat

We report on the construction of a leptin bioassay based on the activation of chicken leptin receptor in cultured cells. A human embryonic kidney (HEK)-293 cell line, stably transfected with the full-length cDNA of chicken leptin receptor together with a STAT3-responsive reporter gene specifically responded to recombinant human and Xenopus leptins. The observed higher sensitivity of chicken lep...

2015
Jin Young Lee Oh Kyung Lim Ju Kang Lee Yongbum Park Cham Kim Jin Won Yoon Ki Deok Park

OBJECTIVE To investigate the question of whether serum leptin levels might be associated with post-stroke depression. METHODS We studied 130 patients who experienced a first episode of stroke of more than three months' duration, without any previous history of depression or speech disorders. Data were collected regarding the patient demographics, depressive mood (Diagnostic and Statistical Ma...

Journal: :Bratislavske lekarske listy 2014
Z Tahergorabi M Khazaei

AIM Obesity is considered as a major health problem. Angiogenic vessels by providing oxygen, nutrients and growth factors trigger growth and survival signals in adipocytes. We aimed to investigate the effect of high-fat diet (HFD) on serum angiogenic biomarkers including vascular endothelial growth factor (VEGF), soluble VEGF receptor 1 (sVEGFR1), nitric oxide (NO) concentrations and their corr...

Journal: :Allergologia et immunopathologia 2007
F Erel M Gulec O Kartal Z Caliskaner S Ozturk H Yaman Y Kurt E Gocgeldic F Ors M Karaayvaz

BACKGROUND Despite improved understanding of the pathophysiology of allergic rhinitis and asthma, the effect of serum leptin level is still controversial. Only a few studies have been performed to investigate the serum leptin levels in allergic rhinitis and asthma, and contradictory results have been observed. OBJECTIVE We aimed to investigate the association between leptin, lipid profiles an...

Journal: :The Journal of clinical endocrinology and metabolism 2000
B A Gower T R Nagy M I Goran A Smith E Kent

Whether use of hormone-replacement therapy (HRT) influences menopause-related changes in body weight is unclear. HRT may affect energy balance by influencing synthesis of the adipocyte-derived hormone leptin. The objectives of this study were to: 1) identify factors influencing circulating leptin in postmenopausal women; 2) determine whether HRT influences serum leptin after adjusting for confo...

2013
Hamed Jafari Vayghan Ali Tarighat Esfanjani Mehrangiz Ebrahimi Mameghani Mohammad Asghari Jafarabadi Sevda Saleh Ghadimi Zahra Lalezadeh

Leptin and adiponectin are two important adipose tissue derived cytokines. Serum adiponectin levels decrease in obesity and chronic disease, whereas leptin shows a positive correlation with inflammation. Given that serum leptin and adiponectin levels vary among different ethnic groups, the aim of this study was to determine the serum levels of leptin and adiponectin in a random sample of appare...

2009
Ruimin Chen Gail J. Mick Rongxian Xu Daoxin Zheng Yanfeng Fan Xiangquan Lin Kenneth L. McCormick

The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23-36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, m...

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