Background: Intravenous application of iron preparations which is a routine treatment of anemia in hemodialysis patients with end-stage renal disease can lead to iron overload in the body. Redox-active iron can catalyze the formation of hydroxyl radicals and initiation of lipid peroxidation, increase oxidative stress and speed up the development of complications in these patients. Objective: In...

Iron overload has not been studied extensively and prospectively in pediatric survivors of allogeneic hematopoietic stem cell transplantation (HSCT); therefore, we conducted a prospective long-term study of 133 survivors of childhood leukemia to assess the incidence of and risk factors for iron overload and to investigate its association with organ dysfunction. One yr after HSCT, the mean serum...

Introduction: Nowadays one of the most important problems of Thalassemia major patients is the additional load of iron and hemosiderosis, the most important consequence of which is deposited iron in myocardial tissue and the incidence of cardiomyopathy caused by hemochromatosis. The aim of this study was to determine the effect of concurrent (resistance-endurance) exercise on NT-pro BNP and...

BACKGROUND Increased cellular iron exposure is associated with colorectal cancer (CRC) risk. Hepcidin, a liver peptide hormone, acts as the primary regulator of systemic iron status by blocking iron release from enterocytes into plasma. Concentrations are decreased during low iron status and increased during inflammation. The role of hepcidin and the factors influencing its regulation in CRC re...

background: increased estimated body iron stores have been recently suggested to be associated with increased risk of acute myocardial infarction (ami); however the question of whether serum ferritin level as an indicator for estimating body iron is an independent risk factor for cardiac events is still questioned. in the present study, we assessed whether serum ferritin was associated with the...

Hepcidin, produced in the liver, is a key regulator of systemic iron metabolism. This study aimed to estimate the significance of hepcidin for diagnosis of iron deficiency anemia (IDA) among children and to determine whether routine hematological parameters and iron profile correlate with hepcidin levels in children in Saudi Arabia. Blood samples from children were analyzed for hematology param...

OBJECTIVE To diagnose and differentiate iron deficiency anaemia (IDA) from anaemia of chronic disorders (ACD) using serum concentration of soluble transferrin receptors (sTfR). METHODS One hundred and seventy six adult anaemic patients were diagnosed on bone marrow examination as IDA and ACD in the Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi from November 2001 t...

Background and Aim: Anemia is a major clinical multifactorial problem in hemodialysis (HD) patients. Iron metabolism is frequently impaired and may complicate the management of anemia. Hepcidin is synthesized in the liver. It is thought to be a key regulator of iron homeostasis. Therefore, we thought to assess prohepcidin level and iron indices in patients on regular HD with and without associa...

The relationship between aluminium toxicity and iron metabolism was studied. Male rats were exposed to aluminium by daily intraperitoneal injection of 40pmolelkg body weight. After 45 days, aluminium intoxified rats had a significant loweredserum ferritin (55%), iron (42%), TIBC (25%) and hemoglobin(31%). At thesame time the serum ceruloplasmin level was elevated by 60%. This result shows t...