The detection of an insulin antagonist in the serum of insulin resistant subjects has been attempted on a number of occasions. In certain instances, the excessive quantities of insulin used in the neutralization experiments in animals may explain the failure to obtain evidence of an insulin antagonist. In the few successful experiments which have been done, little information of a quantitative ...

fenfluramine, an anorexigenic agent, is widely used in the treatment of obesity. besides its anorectic effect, it may also have some effects on general metabolism with the consequence of weight loss. in this study, the effect of fenfluramine on the concentrations of some parameters related to carbohydrate metabolism was investigated. it was shown that the serum insulin level was reduced by 41 %...

abstract          background and objective: vitamins c and e are  the two main antioxidants involved in prevention of type 2 diabetes, by reducing oxidative stress. the aim of this study was to evaluate the effects of vitamins c and e supplementation independently, on serum levels of insulin, high sensitivity c-reactive protein (hs-crp) and resistin in people with type 2 diabetes.         metho...

Glucose tolerance, serum insulin, insulin receptors in epididymal fat tissue, circulating total cholesterol and triglyceride concentrations as well as serum prolactin were studied in obese and lean spontaneously hypertensive rats (SHR) of both sexes. Obese animals displayed insulin resistance and elevated insulin and triglyceride concentrations. Moreover, in obese rats the increased mass of epi...

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity. Methods We aimed determine the risk association of hyperinsulinemia in NMOSD patients seropositive AQP4-IgG and serum levels interleukin (IL)-6 IL-17A compared control group. Serum metabolic (Insul...

    Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in Berberis vulgaris fruit extract (BVFE) which have important role in regulation of serum glucos...

conclusions it seems that rj does not appear to have significant immediate effects on glycemic factors in patients with type 2 diabetes. however, further studies with larger sample sizes and different doses of rj are needed to achieve more precise results. background type 2 diabetes is the fourth major public health problem worldwide. royal jelly (rj) insulin-like activity and blood glucose mod...

Serum starvation is a common cell culture procedure for increasing cellular response to insulin, though the mechanism for the serum starvation effect is not understood. We hypothesized that factors known to potentiate insulin action [e.g., AMP-activated protein kinase (AMPK) and p38] or to be involved in insulin signaling leading to glucose transport [e.g., Akt, PKCζ, AS160, and ataxia telangie...

Gongronema latifolium (GL) is reported to have hepato-protective and nephron-protective ability. Diabetes associated with liver kidney damage. This work was designed evaluate the effect of ethanolic leaf extract on functions in Streptozotocin-induced diabetic rats. 40 Wistar rats both sexes (150g-200g) were divided into five (n=8). Group 1- normal control (received saline placebo orally). 2 rec...