BACKGROUND Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR). OBJECTIVE To develop an equation to predict GFR from serum creatinine concentration and other factors. DESIGN Cross-sectional study of GFR, creatinine clearance, serum creatinine concentration, and demographic and ...

In this study we investigated whether a known delta-aminolevulinic acid dehydratase (ALAD) exon 4 polymorphism has a modifying effect on the association of blood or bone lead level with uricemia and indices of renal function among middle-aged and elderly men. We performed a cross-sectional study of subjects who participated between 1991 and 1995 in the Department of Veterans Affairs Normative A...

INTRODUCTION Creatinine is released into the blood following non-enzymatic hydrolysis of creatine in skeletal muscle, and excreted into urine depending on glomerular filtration. The serum creatinine concentration is widely used as a marker of glomerular function because it increases in patients with decreased glomerular filtration rate (GFR). Although GFR is costly to measure, an estimated GFR ...

BACKGROUND Available data indicate that serum phosphate increases only when glomerular filtration rate (GFR) falls into the low range (<60 mL/min x 1.73 m(2)). GFR and serum phosphate decrease with ageing. This population-based study investigated by age-controlled analyses the relationship of GFR with serum phosphate in adults with GFR above the low range. METHODS Data were collected on age, ...

1. Creatinine metabolism was studied in nine patients with severe chronic renal failure who were nevertheless in a nearly steady state with respect to their creatinine pool. Labelled creatinine was injected intravenously and the specific radioactivity of creatinine in urine was measured during the ensuing 5-7 days. 2. In each patient, the decline in specific radioactivity with time was a single...

Creatinine is widely used as an indirect marker of renal function. However, interfering factors such as diet, exercise and problems with the assay can generate false results and misinterpretation of real kidney function. In this article, we report the dietary effects on serum creatinine during a phase I single dose escalation study and discuss the reasons why serum creatinine should be measured...

OBJECTIVES Cystatin C is emerging as an endogenous marker of glomerular filtration rate. This study sought to assess the usefulness of serum cystatin C as a marker of glomerular filtration rate in comparison with serum creatinine and serum creatinine-based glomerular filtration rate estimations in voluntary kidney donors. MATERIALS AND METHODS Serum cystatin C and serum creatinine were estima...

Bilirubin causes underestimation of serum creatinine in the Jaffé alkaline picrate assay. We report an approach for preventing bilirubin interference by pretreating serum samples with peroxidase and H2O2. The dissociation of bilirubin from albumin and its subsequent oxidation markedly reduces the bilirubin interference and enables accurate determination of creatinine concentrations by the Jaffé...

BACKGROUND Greyhounds frequently have laboratory values that are outside reference intervals established for dogs. Our recognition of increased serum creatinine concentrations in several Greyhounds posed a problem when evaluating a Greyhound with suspected renal disease. OBJECTIVE The purpose of this study was to compare serum creatinine concentrations between Greyhound and non-Greyhound dogs...