Background Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods We prospectively recruited hospitalized adults within 24 h of admission wit...

INTRODUCTION Observational studies suggest statin therapy reduces incident sepsis, but few studies have examined the impact on new organ failure. We tested the hypothesis that statin therapy, administered for standard clinical indications to ventilated intensive care unit patients, prevents acute organ failure without harming the liver. METHODS We performed a retrospective, single-centre coho...

OBJECTIVES: Septic pulmonary embolism is an uncommon but life-threatening disorder. However, data on patients with septic pulmonary embolism who require critical care have not been well reported. This study elucidated the clinicoradiological spectrum, causative pathogens and outcomes of septic pulmonary embolism in patients requiring critical care. METHODS: The electronic medical records of 2...

During a period from 1976 to 1982, we performed gastrointestinal operation on 2406 cases. Among the 2406 operated cases, 135 (5.3%) developed severe infections. There were 36 (26.7 %) cases which fell into the sequential system failure subsequent to these severe postoperative infection. The mortality rate was high at 51.9%. The organ failure began to appear by the second week after the developm...

OBJECTIVE The aim of the study was to determine the prognosis in patients who needed norepinephrine treatment in our institution in relation to the degree of organ failure and the evolution of the disease process. DESIGN Retrospective case note analysis of outcome of those patients who needed norepinephrine according to our institutional regimen. PATIENTS A total of 100 consecutive patients...

Methods This prospective observational study was conducted in a 19-bed polyvalent adult intensive care unit of the “Attikon” University Hospital, between November 2012 and June 2013.TF and TFPA levels were recorded on day of study entry (protocol day 0) and further followed once a week (days 7 and 14 or until they were discharged from ICU or until death). Tissue factor activity (TFa) was measur...

Sepsis is the leading cause of mortality in critically ill patients. In this pathological syndrome, septic shock and sequential multiple organ failure correlate with poor outcome. The pathophysiology of sepsis with acute organ dysfunction involves a highly complex, integrated response that includes activation of number of cell types, inflammatory mediators, and the hemostatic system. Central to...

OBJECTIVE The main intensive care unit (ICU) goal is to avoid or reverse the organ failure process by adopting a timely intervention. Within this context, early identification of organ impairment is a key issue. The sequential organ failure assessment (SOFA) is an expert-driven score that is widely used in European ICUs to quantify organ disorder. This work proposes a complementary data-driven ...

INTRODUCTION Oxidative stress is involved in the development of secondary tissue damage and organ failure. Micronutrients contributing to the antioxidant (AOX) defense exhibit low plasma levels during critical illness. The aim of this study was to investigate the impact of early AOX micronutrients on clinical outcome in intensive care unit (ICU) patients with conditions characterized by oxidati...

Abstract Background Coronavirus disease 2019 (COVID-19) has spread around the world, until now, number of positive and death cases is still increasing. Therefore, it remains important to identify risk factors for in critically patients. Methods We collected demographic clinical data on all severe inpatients with COVID-19. used univariable multivariable Cox regression methods determine independe...