Membrane proteins such as receptors and ion channels undergo active trafficking in neurons, which are highly polarised and morphologically complex. This directed trafficking is of fundamental importance to deliver, maintain or remove synaptic proteins. Super-ecliptic pHluorin (SEP) is a pH-sensitive derivative of eGFP that has been extensively used for live cell imaging of plasma membrane pr...

The evaluation of the gender-specific prevalence of cardiovascular risk factors across socioeconomic position (SEP) categories may unravel mechanisms involved in the development of coronary heart disease. Using a sample of 1704 community dwellers of a Portuguese urban center aged 40 years or older, assessed in 1999-2003, we quantified the age-standardized prevalence of nine established cardiova...

Children of low socio-economic position (SEP) consume poorer diets than those of high SEP; however, there is limited understanding of why socio-economic gradients in diet occur. Some evidence suggests that determinants of dietary intake may differ between SEP groups. The aim of the present study was to determine whether the associations between personal and environmental variables and children'...

BACKGROUND Road traffic injury is a major cause of death among youths. AIMS To estimate mortality differences in family socioeconomic position (SEP) and municipal disadvantage level. METHODS Data on all Norwegians born in 1967-76, gathered from national registries, were linked by a unique national identification number. The 611 654 participants were followed-up for 5 years from age 16 years...

The effects of hypoxic hypoxia on cerebral hemodynamics and somatosensory evoked potential (SEP) were studied in 10 pentobarbital anestheteized dogs. Cerebral blood flow (CBF) was measured using the venous outflow technique and cerebral oxygen consumption (CMRO2) was calculated from the arterio-cerebro-venous oxygen difference times CBF. SEP was evaluated by percutaneous stimulation of an upper...

Members of the SEPALLATA (SEP) MADS-box subfamily are required for specifying the "floral state" by contributing to floral organ and meristem identity. SEP genes have not been detected in gymnosperms and seem to have originated since the lineage leading to extant angiosperms diverged from extant gymnosperms. Therefore, both functional and evolutionary studies suggest that SEP genes may have bee...

OBJECTIVE We examined if those born late-preterm (at 34 to 36 weeks of gestation) differed from those born at term in their maximum attained lifetime socioeconomic position (SEP) across the adult years up to 56 to 66 years, and in intergenerational social mobility from childhood parental SEP to own attained SEP. METHODS Participants were 8993 Finnish men and women of the Helsinki Birth Cohort...

INTRODUCTION Sclerosing encapsulating peritonitis (SEP) is characterized by partial or complete encasement of small intestine by a thick fibrocollagenous membrane. Depending on underlying causes, SEP is divided into primary and secondary forms. Idiopathic SEP is also called idiopathic or abdominal cocoon syndrome. Herein we presented a case of idiopathic SEP. CASE PRESENTATION A 90-year-old m...

The purpose of the present study was to examine the effects of additional in-season speed endurance production versus speed endurance maintenance training regimes on performance in competitive male soccer players. In a randomised controlled trial 18 male sub-elite players were exposed to additional speed endurance production (SEP) or speed endurance maintenance (SEM) training (two additional se...

Purpose To propose a static automated perimetry strategy that increases the speed of visual field (VF) evaluation while retaining threshold estimate accuracy. Methods We propose a novel algorithm, spatial entropy pursuit (SEP), which evaluates individual locations by using zippy estimation by sequential testing (ZEST) but additionally uses neighboring locations to estimate the sensitivity of ...