While there have been remarkable advances in hearing research over the past few decades, there is still no cure for Sensorineural Hearing Loss (SNHL), a condition that typically involves damage to or loss of the delicate mechanosensory structures of the inner ear. Sophisticated in vitro and ex vivo assays have emerged in recent years, enabling the screening of an increasing number of potentiall...

Distal renal tubular acidosis (dRTA) is characterized by the inability to excrete acid in the renal collecting ducts resulting in inappropriately alkaline urine and hyperchloremic (normal anion gap) metabolic acidosis in the context of a normal (or near-normal) glomerular filtration rate. Inborn dRTA can be due to autosomal dominant or recessive gene defects. Clinical symptoms vary from mild ac...

OBJECTIVES To determine the prevalence of refractive and nonrefractive ophthalmologic abnormalities in children with sensorineural hearing loss (SNHL) and to evaluate the overall utility of routine ophthalmological examination in children with SNHL. DESIGN An institutional review board-approved retrospective analysis of ophthalmologic findings in children (18 years and younger) with SNHL seen...

Background: Humans convey their emotions and information to one another through language. Delayed or poor speech can have a profound effect on the social professional life of person.
 Aim Objectives: A study children with poor/delayed in tertiary care centre western U.P. Objectives were as follows • To risk factors for congenital hearing loss poor/no speech. screen them regarding status. a...

Meniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL) and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis), which suggests a shared autoimmune background. Functional variants of several genes involved in the NF-κB pathwa...

UNLABELLED Sensorineural hearing loss (SNHL) related to chronic suppurative otitis media (CSOM) was studied to clarify the involvement of cholesteatomas in this context. AIM to evaluate SNHL related to CSOM and its association with cholesteatomas, disease duration and patients ages. METHODS Retrospective analysis of 115 patients with CSOM with and without cholesteatoma submitted to surgical...

OBJECTIVE To elucidate clinical antecedents of sensorineural hearing loss (SNHL) in very preterm infants. DESIGN Case-control study. SUBJECTS Fifteen children < 33 weeks' gestation with significant SNHL born between 1 January 1990 and 31 December 1994, detected within 9 months of birth, and 30 matched control children. METHODOLOGY Perinatal variables in the two groups were compared using ...

Vestibular end organ impairment is highly prevalent in children who have sensorineural hearing loss (SNHL) rehabilitated with cochlear implants (CIs). As a result, spatial perception is likely to be impacted in this population. Of particular interest is the perception of visual vertical because it reflects a perceptual tilt in the roll axis and is sensitive to an imbalance in otolith function. ...

Pendred syndrome (PDS) and DFNB4 comprise a phenotypic spectrum of sensorineural hearing loss disorders that typically result from biallelic mutations of the SLC26A4 gene. Although PDS and DFNB4 are recessively inherited, sequencing of the coding regions and splice sites of SLC26A4 in individuals suspected to be affected with these conditions often fails to identify two mutations. We investigat...

patients and methods in this cross-sectional study, 791 infants were recruited via non-random sampling. demographic and clinical characteristics of the subjects were gathered, and the automated auditory brainstem response (aabr) test was performed upon admission. afterwards, the subjects were followed-up and re-assessed, using the aabr test. for infants with abnormal aabr results, the auditory ...