The crystal structure of the title Fe(II) complex, [Fe(NCS)(2)(C(7)H(8)N(4)S)(2)(CH(3)CH(2)OH)(2)]·2C(7)H(8)N(4)S, based on the Schiff base ligand pyridine-3-carbaldehyde thio-semicarbazone (pct), results from the cocrystallization of an Fe(II) coordination compound together with two of the pct ligands. The complex unit is mononuclear, with the central Fe(II) ion located on a crystallographic c...

Mixed ligand octahedral Titanium(III) complexes with the tridentate salicylaldehydesemi-, thiosemiand isothiosemicarbazone and pyridine of general formula [Ti(L)(py)3]X(H2L 1 = salicylaldehyde semicarbazone,X=[TiCl3(py)] -, ClO4 .H2O, I . 0.5 I2; H2L 2 = salicylaldehyde thiosemicarbazone, X = [TiCl3(py)] ,[Ti Br3(py)] -, ClO4 . H2O, I3 -; H2L 3 = salicylaldehyde Smethylisothiosemicarbazone,X = ...

Steroidal thiosemicarbazones, semicarbazones and hydrazones have received extensive attention of scientists recently because they exhibit some biological activities such as antibacterial, antiviral and anticancer. Using different steroids as starting materials, through different chemical methods, 24 steroidal compounds with thiosemicarbazone, semicarbazone or hydrazone groups in their structure...

Furacin* (5-nitro-2-furaldehyde semicarbazone) is an antibacterial agent effective against both Gram-negative and Gram-positive organisms (l-3). It has also been studied extensively, along with other nitrofurans, to determine its fate during metabolism in the body (4, 5). Certain of these nitrofurans having chemotherapeutic activity partially withstand metabolic breakdown in the body and are ex...

The structure of the title compound, C11H15N3OS, shows the flexibility due to the methyl-ene group at the thio-amide N atom in the side chain, resulting in the mol-ecule being non-planar. The dihedral angle between the plane of the benzene ring and that defined by the atoms of the thio-semicarbazide arm is 79.847 (4)°. In the crystal, the donor-acceptor hydrogen-bond character of the -OH group ...

Two series of chloroisatin-3-semicarbazones and hydrazones have been designed and prepared by condensing 4-chloro and 6-chloroisatin with several substituted semicarbazides and related bioisosteric hydrazides, respectively. Investigation of in vitro antimicrobial activity of compounds has been performed by agar double dilution method against nine pathogenic bacteria and four pathogenic fungi. T...

In the title compounds, C11H13N3O2S, (I), and C16H15N3O2S, (II), the thio-semicarbazone group adopts an extended conformation. The acetate ester (I) crystallizes with two independent mol-ecules in the asymmetric unit. In the benzoate ester (II), the planes of the two aryl rings are inclined to one another by 46.70 (7)°. In both compounds, there is a short intra-molecular N-H⋯N contact present, ...

Cutaneous leishmaniasis (CL) is a neglected tropical disease, which causes severe skin lesions. Due to the lack of effective vaccines, and toxicity or reduced effectiveness of available drugs in addition to complex and prolonged treatments, there is an urgent need to develop alternatives for the treatment for CL with different mechanisms of action. In our effort to search for new promising hits...

The asymmetric unit of the title compound, C(11)H(11)N(3)S(2)·0.5CH(4)O, contains four thio-semicarbazone mol-ecules and two methanol solvent mol-ecules. Each hydrazinecarbothio-amide mol-ecule adopts an E configuration with respect to the C=N double bond and is stabilized by an intra-molecular N-H⋯N hydrogen bond, resulting in an S(5) ring motif. In the crystal structure, an extensive network ...

The title complex, [AuCl(C18H16N5S)]Cl·1.5H2O, may be considered as a gold(I) compound with the corresponding metal site coordinated by a thio-semicarbazone ligand through the S atom. The ligand adopts an E conformation and the gold(I) atom displays the expected linear geometry with a Cl atom also bonded to the metal ion [Cl-Au-S = 174.23 (5)°]. One of the pyridyl rings is protonated, giving th...