The extent to which epistasis affects the genetic architecture of complex traits is difficult to quantify, and identifying variants in natural populations with epistatic interactions is challenging. Previous studies in Drosophila implicated extensive epistasis between variants in genes that affect neural connectivity and contribute to natural variation in olfactory response to benzaldehyde. In ...

Este escrito gira en torno a una copla popular que lleva al menos un siglo prediciendo el fin de mundo campesino y reflexiona sobre cómo esta resuena con imagen recurrente veredas San Miguel Sema Ráquira (Boyacá): la rancho última habitante quien se sospecha pudo haber muerto tristeza o soledad. En espacio resonancia, teniendo cuenta larga historia migración rural, explora constituye siente pun...

Tujuan penelitian ini yaitu untuk menganalisis dan menjelaskan implementasi pembuktian pertanggungjawaban kerugian uang negara dalam tindak pidana korupsi di Indonesia. Hasil menunjukkan bahwa Pertanggungjawaban wajib dihitung di-declare dengan metode baku menjamin kepastian hukum. Laporan Pemeriksaan keuangan Negara oleh BPK, APIP (BPKP, Inspektorat) Akuntan Publik menjadi dasar pertimbangan b...

Følelser er det modsatte af tanker/erkendelse, som sanselighed ånd, krop sjæl. Idehistorisk derfor gået følelserne, sanseligheden og kroppen. Men den orfiske soma-sema tanke (gr. "kroppen min grav", dvs. kroppen sjælens fængsel) kristendommens frelseslære begynder splittelse i europæisk antropologi, der ser følelser noget lavt suspekt. Hvis ikke moralske, religiøse grunde, så erkendelsesteoreti...

BACKGROUND c-Met mutations play a critical role in the development and progression of primary tumors and metastases. Activation of the HGF/SF-c-Met pathway determines a poor prognosis in non-small-cell and small-cell lung cancer (SCLC) patients. Missense mutations of c-Met have been identified in SCLC patients located in the juxtamembrane (JM) and in the Sema domain. To determine the role of th...

Vascular endothelial growth factor (VEGF) is up-regulated during mesothelial to mesenchymal transition (MMT) and has been associated with peritoneal membrane dysfunction in peritoneal dialysis (PD) patients. It has been shown that normal and malignant mesothelial cells (MCs) express VEGF receptors (VEGFRs) and co-receptors and that VEGF is an autocrine growth factor for mesothelioma. Hence, we ...