BACKGROUND Increased mortality from lymphoid malignancies following exposure to environmental selenium has recently been reported. Moreover, conflicting results have been found in investigations examining the relationship between serum concentrations of selenium and some clinical features of malignant lymphoproliferative diseases. METHODS Serum concentrations of selenium were analyzed by atom...

The influence of application of increasing doses of selenium (0.05 mg, 0.10 mg and 0.20 mg/kg) into soil in pot experiments, with NPK fertilization of spring wheat (Triticum aestivum L., variety Banti), on the biomass yield (grain, straw, roots) and on selenium accumulation was observed. Selenium in the form of sodium selenite (Na2SeO3·5H2O) and the NPK nutrients in the form of LAD-27, Ca(H2PO4...

Selenium is a trace element, essential in small amounts, but it can be toxic in larger amounts. Levels in the body are mainly dependent on the amount of selenium in the diet, which is a function of the selenium content of the soil. Humans and animals require selenium for normal functioning of more than about 30 known selenoproteins, of which approximately 15 have been purified to allow characte...

BACKGROUND Selenium may prevent colorectal cancer. However, several previous studies are small and few investigated the association between selenium and colorectal cancer among women whose selenium metabolism may differ from men. Furthermore, genetic variants in selenoenzymes may be associated with colorectal cancer risk. METHODS This nested case-control study investigated whether serum selen...

Title: EFFECT OF DIETARY SELENIUM STATUS ON T CELL IMMUNITY AND CANCER XENOGRAFT IN NUDE MICE Alexandra Holmstrom, Master of Science, 2010 Directed By: Assistant Professor Wen-Hsing Cheng, Department of Nutrition and Food Science Selenium (Se) is known to regulate carcinogenesis and immunity at nutritional and supranutritional levels. Because the immune system provides one of the main body defe...

Abstract—Selenium is an-antioxidant which is important for human health enters food chain through crops. In Kenya Zea mays is consumed by 96% of population hence is a cheap and convenient method to provide selenium to large number of population. Several soil factors are known to have antagonistic effects on selenium speciation hence the uptake by Zea mays. There are no studies in Kenya that has...

OBJECTIVE The purpose of this study was to examine the relationship between serum selenium levels and the prevalence of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS We conducted a cross-sectional analysis of 8,876 adults > or =20 years of age who participated in the Third National Health and Nutrition Examination Survey. Diabetes was defined as the presence of a fasting plasma gluc...

Studies were performed to assess the role of combined selenium and iodine deficiency in the etiology of endemic myxedematous cretinism in a population in Zaire. One effect of selenium deficiency may be to lower glutathione peroxidase activity in the thyroid gland, thus allowing hydrogen peroxide produced during thyroid hormone synthesis to be cytotoxic. In selenium-and-iodine-deficient humans, ...

Three protocols were used to determine the effects of dietary selenium concentration on the development of gamma-glutamyl-transpeptidase (GGT)-positive foci and hepatocellular carcinoma induced by either diethylnitrosamine (DEN) or N-acetylaminofluorene in rats. In the first experiment, foci were induced by a carcinogenic dose of DEN (100 mg/kg body weight, p.o.) at 20-22 h after two-thirds par...

In the 1996 Nutritional Prevention of Cancer (NPC) trial, selenium supplementation was associated with a reduced risk of prostate cancer. This relationship was further studied in two large well‐ designed clinical trials, but no significant associations were found. However, the study populations in both of these trials had a moderate to high selenium status while the NPC trial population had a l...