One feeding trial and two balance studies were conducted to study the effects of adding arsanilic acid or vitamin E (E) upon utilization of natural or supplemental selenium (Se) (from sodium selenite) in the diet. Eighty weanling pigs were assigned at random to eight dietary treatments in a 23 factorial design. The basal corn-soybean meal diet (containing .036 ppm Se and 6 IU E/kg) was fed alon...

This study reports the first demonstration of a marked reduction in alpha-crystallin chaperone activity in an experimental model of cataract, and the study implicates activation of the cysteine protease calpain II (EC 3.4.22.17) as the in vivo protease responsible for decreased chaperone activity. Chaperone activity of normal alpha-crystallin from lenses of young rats was assayed by measuring a...

EDWARDS, P. R. AND EWING, W. H. 1955 Identification of Enterobacteriaceae. Burgess Publishing Company, Minneapolis, Minnesota. EYRE, J. W. H. 1908 Milroy lectures on melitensis septicemia. Lancet, 1, 1747. LEVINE, M. AND TANIMOTO, R. H. 1954 Antagonisms among enteric pathogens and coliform bacteria. J. Bacteriol., 67, 537-541. NORTH, W. R. AND BARTRAM, M. T. 1953 The efficiency of selenite brot...

Ascorbic acid and selenium are two nutrients that seem to have a preventive potential in the process of carcinogenesis; because of a possible synergistic action that may produce an enhanced anticarcinogenic effect. Interaction between these nutrients have been reported. Results indicate that the protective effect of the inorganic form of selenium (Na Selenite) was nullified by ascorbic acid, wh...

Sodium selenate and sodium selenite are used as supplements to poultry and livestock feed to promote growth and prevent selenium deficiency diseases. Both compounds have been found in chemical waste sites. Thirteen-week toxicity studies were conducted by administering the chemicals to groups of male and female F344/N rats and B6C3F1 mice in drinking water. Animals were evaluated for hematology,...

Selenium (Se) is an essential nutrient for humans and animals. The Se RDA for adult humans is 55 mug/d; however, dietary amounts as high as 200 mug/d in the highly available form of selenomethionine in yeast were shown to reduce the incidence of certain cancers. A number of natural foods contain relatively high amounts of Se; for the most part, however, the availability of food Se for absorptio...

Massive cortical cataract was produced 15-30 days after a single injection of an overdose of sodium selenite into 14-day-old rats. Most of the cortical cataract appeared to be due to extensive liquefaction of cortical fibers. Water influx, following initial damage to the epithelium by selenium, and action of lens proteases were probable mechanisms for the extensive liquefaction. Remarkably, sel...

For 8 wk 5 groups of 10 men each were given 0.5 g/day DL-methionine, 150 micrograms Se/day as sodium selenite with or without methionine or 150 micrograms Se/day as selenomethionine with or without methionine. Twenty subjects received placebo as controls. Initially plasma Se rose more rapidly than RBC Se. Increases in Se levels were significantly greater with selenomethionine than with the sele...

Cataract is clouding of the eye lens that reduces the amount of incoming light and results in deteriorating vision. Blindness is thought to reach 75 million by 2020. Of these, unoperated cataract may be expected to account for at least 35 million. Thus, the burden of cataract is increasing remorselessly. Embelica officinalis is reported to have a very good antioxidant property and thus we hypot...

Microbes in Haughton Crater Sulfates: Impact craters are of high interest in planetary exploration because they are viewed as possible sites for evidence of life [1]. Hydrothermal systems in craters are particularly regarded as sites where primitive life could evolve. Evidence from the Miocene Haughton impact structure shows that crater hydrothermal deposits may also be a preferred site for sub...